摘要
目的:探讨I L-1A-889的基因多态性与慢性牙周炎及侵袭性牙周炎易感性的相关关系。材料和方法:选取华南地区慢性牙周炎患者57例,侵袭性牙周炎患者45例,健康志愿者50例,从颊黏膜脱落细胞中获得DNA,用PCR-RFLP法检测IL-1A-889基因型的分布。结果:慢性牙周炎患者的IL-1A-889基因型的分布以及T等位基因的出现频率显著高于对照组,侵袭性牙周炎患者与对照组相比无显著性差异。结论I:L-1A-889基因多态性与深圳市慢性牙周炎患者的易感性有显著相关性。
Objective To discuss the association of the IL1A（-889） gene polymorphism in Shenzhen individuals with chronic and aggressive periodontitis.Material and methods DNA was obtained from oral swabs of 152 shenzhen individuals and was amplified using the polymerase chain reaction（PCR）.Products were submitted to digestion and were analyzed by electrophoresis to distinguish the C and T alleles through Restriction Fragment Length Polymorphism method（RFLP）.Results A significant difference in the genotype distribution was observed when comparing the chronic periodontitis group with the control group.Moreover,a higher incidence of the T allele in the chronic periodontitis group was detected when compared with the control group.No statistical difference was observed when the aggressive periodontitis group was compared with the control group.Conclusion These data show an association of the IL1A（-889） polymorphism with chronic periodontitis in Shenzhen individuals.
出处
《中国美容医学》
CAS
2011年第1期71-73,共3页
Chinese Journal of Aesthetic Medicine
基金
深圳市科技计划项目(200703095)
深圳市福田区卫生科技资助项目(FTWS201022)
