摘要
目的通过Meta分析探讨IL-1β基因多态性与慢性阻塞性肺疾病(COPD)易感性的关系。方法计算机及手工检索1980年1月至2013年1月发表的关于IL-1β基因多态性和COPD易感性关系的文献资料。根据纳入及排除标准筛选文献并提取数据。Meta分析采用RevMan5.0.25和Stata11.0软件进行。合并效应采用比值比(OR)和95%可信区间(95%CI)进行评价。发表偏倚通过漏斗图直观判断和Egger回归法、Begg秩相关法定量检测。敏感性分析为剔除不符合H-W平衡的文献后重新进行Meta分析。5篇文献(6项研究)被纳入Meta分析,共有749例COPD患者及923例对照纳入研究。结果 Meta分析结果表明,IL-1β-511C/T基因多态性与COPD易感性无关联(Tvs.C︰OR=0.97,95%CI=0.76～1.24;TTvs.CC︰OR=0.93,95%CI=0.55～1.59;CT+TTvs.CC︰OR=1.25,95%CI=0.98～1.58;TTvs.CT+CC︰OR=0.82,95%CI=0.64～1.05),IL-1β-31T/C基因多态性与COPD易感性亦无明显联系(Cvs.T︰OR=0.99,95%CI=0.86～1.15;CCvs.TT︰OR=0.99,95%CI=0.72～1.35;CT+TTvs.CC︰OR=1.21,95%CI=0.94～1.55;TTvs.CT+CC︰OR=0.80,95%CI=0.63～1.03)。结论 IL-1β-511C/T、-31T/C基因多态性与COPD易感性无关。
Objective To study the association between interleukin-1β （IL-1β） gene polymorphisms and chronic obstructive pulmonary disease（COPD） by Meta-analysis. Methods The literatures published was searched before January 2013 about the association between IL-1β gene polymorphisms and COPD and extracted data according to inclusion and exclusion criteria. Statistical analysis was performed by using RevMan 5.0.25 and STATA 11.0 software. The association between IL-1βgene polymorphism and COPD risk was measmed by the odds ratio （OR） with 95% confidence interval （CI）. The publication bias was tested by Begg＇ s funnel plots and Egger＇ s linear regression method. Sensitivity analysis was performed by excluding the study not consistent with Hardy-weinberg （H-W）. Six case-control studies with a total of 749 COPD patients and 923 controls were retrieved. Results Meta-analysis results showed no significant association between IL-1β-511 C/ T polymorphism and COPD risk（T vs C： OR =0.97, 95% CI =0.76 - 1.24; TT vs CC： OR =0.93, 95% CI =0.55 -1.59; CT＋TFvsCC：OR=l.25,95%CI=0.98-1.58;TTvsCT＋CC：OR=0.82,95% CI=0. 64 -1.05 ）. No significant association was found between IL-113-31C/T polymorphism and COPD risk（ C vs T： OR=0.99, 95% CI=0.86 -1.15; CC vs TT：OR=0.99, 95% CI=0.72-1.35; CT＋TT vs CC：OR=1.21, 95% CI=0.94-1.55;TFvsCT＋CC：OR=0.80,95%CI=0.63-1.03）. Conclusion IL-ll3-511C/ T, -31T/C polymorphisms might not be risk factors for COPD.
出处
《中华肺部疾病杂志（电子版）》
CAS
2013年第2期15-18,共4页
Chinese Journal of Lung Diseases(Electronic Edition)
