摘要
目的研究三阴性乳腺癌VEGF基因表达的情况和与淋巴管密度的关系。方法标本为219例乳腺癌标本,其中三阴性乳腺癌42例,非三阴性乳腺癌标本177例,应用免疫组化的方法检测标本的VEGF基因表达的情况及应用D2-40标记检测淋巴管浸润和淋巴管密度。结果 VEGF因在三阴性乳腺癌高表达(59.5%),与淋巴结有无转移相关(P<0.01),与淋巴管浸润和淋巴管密度相关(P<0.05),而与年龄、肿瘤大小、病理类型和分期无关(P>0.05);VEGF基因在三阴性和非三阴性乳腺癌高表达(59.5%,40.7%),差异有显著性(P<0.05)。结论 VEGF基因在三阴性乳腺癌中高表达,它的阳性表达与区域淋巴管的形成和浸润有关,参与三阴性乳腺癌的发生和发展,在三阴性乳腺癌淋巴转移方面起着重要作用。
Objective To Research the expressions of the VEGF and the relationship with lymph vessel density in triple negative breast cancer.Methods 219 cases were selected from January 2006 to December 2009 in our hospital including 42 triple negative breast cancer cases and 177 non-triple negative breast cancer cases.The expressions of VEGF and D2-40 were evaluated by immunohistochemical method.Results The expressions of the VEGF in triple negative breast cancer were high（59.5%）,and they were positively correlated with lymph node metastasis（P0.01）,lymph vessel invasion and lymph vessel density,but they were negatively correlated with age,the size of tumor,the type of pathology and TNM stage（P0.05）.The expressions of the VEGF gene in triple negative breast cancer and non-triple negative breast cancer were high（59.5,40.7%）,and they were significantly different（P0.05）.Conclusion The expressions of the VEGF gene in triple negative breast cancer are high.They may have an important role in lymph metastasis of triple-negative breast cancer.
出处
《淮海医药》
CAS
2011年第1期7-9,共3页
Journal of Huaihai Medicine
