摘要
目的探讨乳腺癌组织中淋巴管密度(LVD)与临床病理参数的关系。方法采用免疫组化方法对100例乳腺癌组织和20例乳腺纤维腺瘤组织中LYVE-1的表达进行检测,计数LVD,分析LVD与乳腺癌淋巴结转移及其它病理参数之间的相互关系。结果乳腺癌组织中LVD显著高于乳腺纤维腺瘤组织(P<0.01),有淋巴结转移的乳腺癌组织LVD显著高于无淋巴结转移者(P<0.01)。LVD与年龄、肿瘤大小、ER、PR、c-erbB2无关(P>0.05),与病理分期显著相关(P<0.01)。结论 LVD与乳腺癌的淋巴结转移有关,可作为乳腺癌淋巴结转移的生物学指标。
Objective To investigate the lymphatic vessel density（LVD）and its clinical significance in breast cancer.Methods Immunohistochemistry was used to detect the expression of LYVE-1 in the tissues from 100 patients with breast cancer tissues and 20 patients with breast fibroadenoma.Lymphatic vessel density（LVD）was counted,and the correlation between the LVD and lymph node metastasis and other clinicopathological parameters was then analyzed.Results LVD was significantly higher in the tissues from breast cancer than that from breast fibroadenoma（P0.01）.In breast cancer,LVD in the sample with lymphatic metastasis was significantly higher than that in the sample without lymphatic metastasis（P0.01）.There were no correlation between the LVD and age,tumor size,ER,PR,c-erbB2（P0.05）,but LVD was significantly correlated with histological grade（P0.01）.Conclusion LVD is significantly correlated with breast cancer lymphatic metastasis.LVD may serve as a biologic marker for lymphatic metastasis in breast cancer.
出处
《实用癌症杂志》
2010年第3期265-267,共3页
The Practical Journal of Cancer
基金
宁波市医学科技计划项目(2006037)
