摘要
目的了解河南省驻马店市HIV单阳家庭的基本特征及随访管理情况。方法收集HIV单阳家庭阳性者的基本信息、医疗行为、性行为特征、及CD4+ T淋巴细胞变化情况,并采集阴性配偶的血样检测HIV血清阳转情况。结果本次调查共随访3 724户HIV单阳家庭,阴性配偶中有3 718人进行HIV检测,13人出现HIV阳转。最近1次性生活安全套使用率为98.9%。治疗病例组CD4+ T淋巴细胞计数呈明显上升趋势;换药组CD4+ T淋巴细胞计数变化较为稳定;未治疗组CD4+T淋巴细胞计数变化未见统计学差异。结论驻马店市HIV单阳家庭阴性配偶的血清HIV抗体阳转率较低。接受抗病毒治疗后效果明显,CD4+ T淋巴细胞计数明显上升,而未治疗的HIV感染者和病人的CD4细胞计数变化规律还需进一步开展研究,以期为选择抗病毒治疗时机和修改抗病毒治疗策略提供参考。
Objective To understand the characteristics and follow-up management of HIV single-infection couples in Zhumadian,Henan Province.Methods Information on medical,sexual behaviors and CD4 count changes were collected,and blood specimens of the HIV-negative partners were collected for testing HIV.Results A total of 3 724 HIV single-infection couples were followed up in Zhumadian and 3 718 negative partners were tested for HIV infection in which 13 people showed HIV sero-positive conversion.The rate of condom use during recent sexual intercourse was 98.9%.There was a rising trend in CD4＋T lymphocyte counts in treatment group,and more stable in drug change group,while no significant difference was observed in untreated group.Conclusions HIV sero-positive conversion was lower among with HIV single-infection couples in Zhumadian.With the availability of HAART（highly active antiretroviral treatment）,CD4 cell count was increased gradually.However,the CD4 cell counts variations need further study in untreated people to choose the treatment time and strategy.
出处
《中华疾病控制杂志》
CAS
2011年第1期39-41,共3页
Chinese Journal of Disease Control & Prevention
