摘要
目的:研究洋葱挥发油离体对人肝癌细胞株(QCY-7703)、人胃癌细胞株(MGC-803)、人宫颈癌细胞株(Hela)、人肺腺癌细胞株(SPC-A-1)的增殖抑制作用和在体对小鼠肉瘤S180及小鼠艾氏腹水癌的抑制作用。方法:采用MTT法检测不同剂量的洋葱挥发油对4种肿瘤细胞增殖的影响,复制小鼠肉瘤S180和小鼠艾氏腹水癌模型,检测不同剂量(1000、500、250mg·kg-1)的洋葱挥发油对小鼠肿瘤的抑制作用,比较其抑制率。结果:洋葱挥发油离体和在体实验中对肿瘤细胞均具有较强的增殖抑制作用。结论:洋葱挥发油能抑制多种肿瘤细胞的增殖,对肿瘤细胞有明显的细胞毒性作用。
OBJECTIVE： To study the in vitro inhibition effect of volatile oil extracts of Allium cepa on the proliferation of QCY-7703, MGC-803, Hela, SPC-A-1 cells and the in vivo inhibition effect on sarcoma S180 and Ehrlich ascites carcinoma in mice. METHODS： MTT assay was used to detect the effect of volatile oil extracts of A. cepa with different dose on the proliferation of 4 kinds of tumor cells. We established sarcoma S180 and ehrlich ascites carcinoma model, detected the inhibition effect of volatile oil extracts of A. cepa with different dose on tumor and compared their inhibition rate. RESULTS： Volatile oil extracts of A. cepa have the distinct in vitro and in vivo inhibition effect on the proliferation of tumor cells. CONCLUSION： Volatile oil extracts ofA. cepa can inhibit the proliferation of variety of tumor cells, and it has cytotoxic effect on tumor ceils.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第7期592-594,共3页
China Pharmacy
关键词
洋葱挥发油
体内
体外
抗肿瘤活性
Volatile oil extracts ofAllium cepa
In vivo
In vitro
Anticancer effect
