摘要
目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与代谢综合征(MS)的相关性,观察病人血浆脂联素水平,并分析是否与合并MS有关。方法测量43例OSAHS病人和20例对照组身高、体重,血压,空腹血糖(FPG),餐后2小时血糖,血脂等代谢综合征(MS)相关指标。PSG测定43例OSAHS病人的AHI、最低血氧饱和度(%)。应用ELISA方法测定血浆脂联素水平。并根据MS诊断标准将OSAHS病人分为合并MS组和无MS组。结果不同程度OSAHS病人之间血脂紊乱和高血压的发生率不同(P<0.05)。OSAHS与MS相关,重度OSAHS病人MS的发生率明显升高(P<0.05)。OSAHS病人脂联素水平降低,中、重度OSAHS病人脂联素的水平低于轻度OSAHS病人(P<0.05)。AHI和最低血氧饱和度是血浆脂联素水平的重要影响因素。OSAHS合并MS脂联素水平更低,(P<0.05)。结论 OSAHS与MS密切相关,OSAHS病人脂联素水平降低,合并MS者脂联素水平更低。OSAHS与MS并存可能增加了心血管疾病的风险。
Objective To investigate the association between obstructive sleep apnea hypopnea syndrome（OSAHS） and metabolic syndrome（MS） in male Chinese patients.To investigate the plasma adiponectin level in OSAHS,analyze whether their plasma adiponectin levels were relative to the concurrent presence of MS.Methods All patients and the control group had been detected MS-associated parameters such as body mass index（BMI）,blood pressure（BP）,fasting plasma glucose（FPG）,2 h postpradial plasma glucose（2hPG）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,and the plasma adiponectin level.Polysomnography was examined during sleep,polysomnography parameters such as the apnea-hypopnea index（AHI）,the minimum oxygen saturation were detected.Results The complication of MS in the severe group of OSAHS was much higher than that in other groups（P0.05）.It was found that the adiponectin were lower in the subjects with OSAHS than in those without OSAHS.Among the subiects with OSAHS,the adiponectin were lower in moderate and severe groups of OSAHS（P0.05）.The minimum oxygen saturation and AHI are important in the adiponectin.Furthermore,the adiponectin were lower in those with the concurrent presence of MS than in those without MS（P 0.05）.Conclusion OSAHS is closely associated with MS in male patients.The adiponectin were low in OSAHS.The adiponectin were lower with the concurrent presence of MS in OSAHS.
出处
《中国实验诊断学》
北大核心
2011年第1期119-122,共4页
Chinese Journal of Laboratory Diagnosis
