摘要
目的：探讨根除幽门螺杆菌（helicobacter pylori，iqP）是否对功能性消化不良（fhctional dyspepsia，FD）患者的症状具有长期改善作用。方法：符合罗马Ⅲ诊断标准的Hp阳性FD80例随机分为治疗组和对照组：治疗组给予奥关拉唑20mg、阿莫西林1000mg、克拉霉素500mg各2次／天三联抗HP治疗；对照组给予奥关拉唑20mg2次／d和多潘立酮10mg3次／d，疗程均为1周。治疗后随访1年，在治疗后1个月及随访1年后行14C-尿素呼气试验（14c—UBT），并在治疗前后对症状进行评分，评分结果采用t检验。结果：治疗组1人失访，Hp根除率为89．7％（35／39），复发率为2．9％（1／34）。治疗组中Hp根除者的症状积分在治疗1月末和随访1年时分别为（1．6±0．6）、（1．9±0．8），分别显著低于对照组（2．8±0．8）、（3．8±1．1），差异有统计学意义（P〈0．05）；而Hp持续感染组的症状积分与对照组相比无明显差异（P〉0．05）。在HP根除组中，治疗后1月、1年时的积分（1．6±0．6、1．9±0．8）较治疗前症状积分（4．8±1．7）均明显下降，差异具有统计学意义（P〈0．05）；而HP持续感染组中，治疗前症状平均评分为（4．7±1．8），随访1月及1年时分别为（2．8±1．0、3．6±0．9），前后比较差异无显著性（P〉0．05）。结论：根除Hp可在较长时间内改善Hp阳性FD患者的症状。
Objective：To investigate the effects of Helicobacter pylori （Hp） eradication on the symptoms of Hp-positive patients with functional dyspepsia （FD）. Methods ： A total of 80 Hp-positive FD patients were randomly allocated into two groups ： patients in treatment group received therapy of 20 mg omeprazole, 1000 mg amoxicillin and 500 mg clarithromycin twice daily, but those in the control group received treatment of 20 mg f omeprazole twice daily and 10 mg domperidone three times daily. The treatment course for both groups were seven days. A follow up of 1 year was conducted. The status of Hp infection was determined by 14C-UBT at 1 month and 1 year after the eradication therapy. Symptom scores in the two groups were compared. Results ： The rate of Hp eradication was 89.7% （35/39）in the treatment group, HP recurent rate was 2.9 % （1/34）.. The symptom scores in eradication group at 1 month and 1 year after the eradication therapy （1.6 ± 0.6,1.9 ± 0.8 ）were significantly lower than that in the control group（2.8 ± 0.8,3.8± 1.1 ）（ P 〈 0.05）. The symptom score in patients with persistent Hp infection in thetreatment group was not significantly different from that that in the control group （ P 〉 0.05）. The symptom scores in eradication group at 1 month and 1 year after the eradication therapy （1.6 ± 0.6,1.9± 0.8 ）were significantly lower than that before treatment （ P 〈 0. 05） ,but the symptom score in patients with persistent Hp infection in the treatment group after the eradication therapy was not significantly different from that before eradication therapy （ P 〉 0.05）. Conclusion ：The symptoms of Hp-positive FD patients can be obviously improved for a long time by Hp eradication therapy.
