摘要
脑缺血再灌注导致神经元损伤,凋亡相关基因及蛋白被激活,与此同时机体内释放大量的细胞因子诱发凋亡发生。目前研究表明,脑缺血再灌注后神经细胞凋亡的主要机制为线粒体损伤、钙超载及氧自由基的累积等。通过对以上机制的深入研究有助于开发新的脑保护药物,并进一步明确各种脑保护药物的治疗靶点和疗效。
Cerebral ischemia-reperfusion results in damage on neuron,leading to genes and proteins related to apoptosis activation.At the same time,generous cytokines released after cerebral ischemia-reperfusion can induce the apoptosis of the neuron.Many current studies have showed that the major damage mechanisms on apoptosis of the neuron are mitochondrion impairment,calcium overload,increased levels of oxygen radicals and so on.The advance research on the mechanism contributes to explore new neuroprotective drugs,and further identify the target and therapeutic effect of drug treatment.
出处
《中国康复理论与实践》
CSCD
2010年第12期1140-1143,共4页
Chinese Journal of Rehabilitation Theory and Practice
基金
"重大新药创制"科技重大专项(2009ZX09103-366)
国家自然科学基金项目(30973893)
北京市自然科学基金项目(7102077)
