摘要
为研究镁在脑缺血早期对神经元保护作用的机制，用电凝法建立大鼠大脑中动脉缺血模型，在造模前给大鼠注射２０ｇ／Ｌ硫酸镁，观察镁对脑组织中谷氨酸（Ｇｌｕ）及一氧化氮（ＮＯ）含量的影响。结果显示，高浓度镁可明显降低脑缺血皮质中Ｇｌｕ、ＮＯ含量，在缺血组Ｇｌｕ、ＮＯ的峰值浓度分别为９．８７、４４．９７ｎｍｏｌ／ｇ，而在加镁组两者浓度分别为７．６８、３３．９２ｎｍｏｌ／ｇ。提示：镁对脑缺血早期神经元的保护作用与其降低脑组织中Ｇｌｕ及ＮＯ含量有关。
To study the mechanism of protective role of Mg2+ on neurons in the early stage of focal cerebral ischemia, the model of focal cerebral ischemia was established by occluding the middle cerebral artary. Before ischemia, 20 g/L magnesium sulfate was injected intravenously into the rat to investigate the effect of Mg2+ on nitric oxide (NO) and glutamate (Glu) contents in occlusion cortex. The results demonstrated that high concentration of Mg2+ could obviously decrease the contents of NO and Glu in occlusion cortex. In ischemia group, the peak contents of Glu and NO were 987 nmol/g, 4497 nmol/g respectively. In the Mg2+ treated group, the peak contents of Glu and NO were 768 nmol/g, 3392 nmol/g respectively. The results suggested that the decerease of Glu and NO contents may contribute to the protective roles of Mg2+ in neurons in the early stage of cerebral ischemia.\;
出处
《同济医科大学学报》
CSCD
1999年第3期238-240,共3页
Acta Universitatis Medicinae Tongji
关键词
硫酸镁
脑缺血
谷氨酸
一氧化氮
magnesium sulfate
\ cerebral ischemia
\ glutamate
\ nitric oxide
\ rat
