摘要
目的 :探讨硫酸镁对新生大鼠缺氧缺血性脑损伤 (HII)的作用机制 ,为在临床应用于HII的治疗提供一定的实验依据。方法 :将 6 0只 7日龄大鼠随机分为四组 :(1)假手术组 ,(2 )缺氧缺血组 (HII组 ) ,(3)缺氧缺血前组 (前治疗组 ) ,(4)缺氧缺血后组 (后治疗组 )。在前、后治疗组均给予硫酸镁腹腔注射 ,观察不同时间脑组织中总钙和一氧化氮 (NO)的变化。结果 :与假手术组比较 ,HII组脑组织中总钙和NO均明显升高 ;而前治疗组则较HII组要明显下降 ,后治疗组也较HII组下降 ,差异有统计学意义。结论 :钙与一氧化氮在HII的发病过程中起重要作用 ,硫酸镁可降低HII脑组织中钙与一氧化氮的水平 ,在HII的防治方面具有一定的神经保护作用。
Objective To study the mechanism of magnesium sulfate acting on newborn rats that have hypoxic-ischemic injury (HII),in order to provide experimental basis for clinical application of magnesium sulfate.Methods:Seven days old rats( n =60) were randomly divided into four groups:(1) the false surgical group,(2)the hypoxic ischemic injury group (HII group),(3)the pretreatment group, and (4) the post treatment group.The magnesium sulfate was intraperitoneally administered to observe the change of total calcium(TCa) and nitric oxide(NO)levels in the pretreatment group or the post treatment group at different times.Results:Compared with the false surgical group,TCa and NO increased significantly in the HII group.TCa and NO decreased evidently more in the pretreatment group and the post treatment group than those in the HII group did.The result had statistically significant( P <0.05).Conclusion:The calcium and NO have important roles in the development of HII.Magnesium sulfate can decrease calcium and NO levels and has some neuroprotective effects against hypoxic ischemia.
出处
《江西医学院学报》
CAS
2002年第4期8-11,共4页
Acta Academiae Medicinae Jiangxi
关键词
硫酸镁
缺氧缺血性脑损伤
实验研究
治疗
新生儿
magnesium sulfate
hypoxic ischemic
brain injury
calcium
nitric oxide
animals, laboratory
rats
