摘要
目的：为观察了解谷氨酸（Ｇｌｕ）和γ－氨基丁酸（ＧＡＢＡ）在发生脑缺血－再灌注损伤时的变化规律。方法：采用Ｌｏｎｇａ＇ｓ方法建立鼠大脑中动脉脑缺血－再灌注模型，观察了正常对照组，单纯缺血２小时，单纯缺血３小时，缺血２小时－再灌注１小时，缺血３小时－再灌注１小时，Ｇｌｕ和ＧＡＢＡ的变化及二者之间的关系。结果：发生再灌注损伤时，Ｇｌｕ和ＧＡＢＡ的比例与正常对照组有显著差异（Ｐ＜０．０１）。结论：在缺血－再灌注损伤发生过程中，脑组织内不仅是Ｇｌｕ和ＧＡＢＡ含量发生变化，而且二者比例严重失调，以上两个方面在脑缺血－再灌注损伤中可能起一定作用。
Objective: To investigate the change pattem of Glu and GABA (gamma aminobutyric acid) during ischemic reperfusion. Methods: Ischemic reperfusion rat model were established by longa's method that were divied into 5 groups: Normal control groups, merely ischemic two hour, merely ischemic three hour, ischemic two hour reperfusion one hour, is chemic three hour reperfusion one hour. Result: The siguificant difference of the Glu/GABA ratio among the different groups were obeserved. Conclusion: Changes in levels and ratio of Glu and GABA may play a important role in brain ischemic injury and reperfusion injury.
出处
《中华神经外科杂志》
CSCD
北大核心
1997年第4期219-221,共3页
Chinese Journal of Neurosurgery
基金
国家自然科学基金
关键词
脑缺血
再灌注损伤
兴奋性
氨基酸
Ischemia Reperfusion injury Excitatory amino acids
