摘要
目的探讨阿奇霉素和左氧氟少星快速（2d）治疗呼吸道肺炎支原体（Mp）感染的效果和可行性，为治疗Mp感染提供快捷途径。方法采用随机和对照的方法前瞻性观察随机收治的141例呼吸道Mp感染患者，年龄19～70（平均41．2）岁，分三组（性别、年龄相匹配）。组1，61例，每日予阿奇霉素10mg／kg，1次／d，po，疗程7d。组2，56例，每日子阿奇霉素10mg／kg，1次／d，po；左氧氟沙星200mg，3次／d，疗程5d。组3，24例，每日予阿奇霉素30mg／kg，1次／d，po；左氧氟沙星600mg（体重〈50kg者400mg），3次／d，疗程2d。疗程结束后随访。结果三组完成观察的分别为54、48和22例。组1、2、3，疗程结束后症状消失率分别为88．9％（48／54），91．7％（44／48）和95．5％（21／22）。组3疗效显著快于组1和组2（P〈0．001），组2显著快于组1（P〈0．001）。小于30岁和治疗及时的患者症状消失快于60岁以上（P〈0．05）和未及时治疗的患者。三组均未出现严重不良反应。随访6mo～3a，未发现异常。结论大剂量阿奇霉素和左氧氟沙星联用治疗Mp感染安全方便，起效快，疗程短，清除Mp彻底。
Objective To investigate the effect and feasibility of high-dose azithromycin and levofloxacin on treating respiratory Mycolasma pneumoniae （Mp） infection. Methods 141 respiratory Mp infected patients with average aged at 41.2 years （ranged 19-70 years） were enrolled and randomized into three groups. Group 1 contained 61 patients and received azithromycin 10 mg/kg, orally, daily for 7 days; Group 2 included 56 subjects and received azithromycin 10 mg/kg, orally, daily, and levofloxacin 200 mg orally, 3 times daily for five days. Group 3 contained 24 subjects and received azithromycin 30 mg/kg, orally, daily and levofloxacin 600 mg （bw. 〈50kg, 400 rag） orally, twice/day for two days. Results 54, 48 and 22 subjects in group l, 2 and 3 completed the follow up visits, respectively. After the last dosage, the symptoms disappeared in 88.9% （48/54）, 91.7% （44/48） and 95.5% （21/22） for group 1, 2 and 3, respectively. Overall, the treatment courses was significantly shorter in group 3 than that in group 1 and 2 （P〈0.001）, and group 2 has shorter treatment than group 1 （P〈0.001）. Subjects 〈 30 years old recovered significantly quicker than those 〉60 years old （P〈0.05）. No severe side-effects were observed in all three groups during the study and subsequent 6-36 months follow-up. Conclusions High-dose azithromycin and levofloxacin for respiratory Mp infection is a safe and effective treatment regimen with a shortened treatment course.
出处
《世界感染杂志》
2010年第5期287-290,共4页
World Journal of Infection
关键词
肺炎支原体
呼吸道感染
阿奇霉素
左氧氟沙星
Mycolasma pneumoniae
Respiratory infection
Azithromycin
Levofloxacin
