摘要
目的观察慢性移植物抗宿主病(cGVHD)狼疮样小鼠模型肾组织中骨形成蛋白7(BMP-7)的表达并探讨雷公藤多苷对其影响。方法以泼尼松为阳性对照,观察雷公藤多苷对模型小鼠肾脏BMP-7表达的影响,并进一步分析其对肾脏病理和功能损害的影响。结果雷公藤多苷具有与泼尼松相似的防止和减轻狼疮样小鼠肾功能恶化、肾组织病理改变的作用,这种作用与上调狼疮小鼠肾组织中BMP-7表达相关。结论雷公藤多苷减轻狼疮肾炎病理改变的机制与其显著上调BMP-7的表达有关。
Objective： To investigate bone morphogenetic protein 7（BMP-7） expression in the chronic graft-versus-host disease（cGVHD） murine lupus nephritis model and to study the effect of tripterygium glycosides on it.Methods： Compared with the prednisone as positive control,the BMP-7 expression was observed by tripterygium glycosides to model.And then,the pathological change and the function damage were observed by the model.Results： The effect,which prevent or decrease the function deterioration and the pathological change,was related to the increase of BMP-7 expression.Conclusion： That the pathological change could be decreased by the tripterygium glycosides may be related to increase significantly the BMP-7 expression.
出处
《中国中医急症》
2010年第11期1907-1910,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
河北省中医药管理局资助课题(No.2008081)
关键词
移植物抗宿主病
狼疮肾炎
小鼠
雷公藤多苷
骨形成蛋白7
Graft-versus-host disease（GVHD）
Lupus nephritis
Mice
Tripterygium glycosides
Bone morphogenetic protein 7（BMP-7）
