摘要
目的探讨益肾排毒方抗肾纤维化的机制,为中药复方防治肾纤维化提供依据。方法采用益肾排毒方和尿毒清颗粒,分别干预腺嘌呤导致的肾间质纤维化模型Wistar大鼠。分6组:正常组、模型组、对照组(尿毒清颗粒)、治疗组(益肾排毒方低、中、高剂量)。检测大鼠TGF-β1、ColⅣ、SOD。结果益肾排毒方可以降低TGF-β1、ColⅣ水平,增高SOD水平,与模型组比较,差异均有统计学意义(P<0.05)。结论益肾排毒方具有抗腺嘌呤致慢性肾衰竭大鼠肾纤维化的作用。
Objective To discuss the mechanism of Yishen Paidu decoction resisting renal fibrosis and to provide basis of herbal compound in the treatment of renal fibrosis. Methods Yishen Paidu decoction and Niaoduqing particles were caused by adenine treatment of renal interstitial fiber model Wistar rats, they were divided into six groups： normal group,model group and control group （Niaoduqing particles）, the treatment group （low, medium and high doses）. To detect TGF-β1. Col IV. SOD. Results Yishen Paidu decoction can reduce levels of TGF-β1, Col IV , increased levels of SOD. Compared with model group, the difference was statistically significant（P〈0.05）. Conclusion Yishen Paidu decoction had the effect of anti-renal fibrosis in adenine rats.
出处
《长春中医药大学学报》
2017年第2期195-197,共3页
Journal of Changchun University of Chinese Medicine
基金
辽宁省科学事业公益研究基金项目"益肾排毒方治疗腺嘌呤致慢性肾衰竭大鼠模型的药效学研究"(2012002012)
沈阳市科技计划项目"益肾活血降浊法治疗腺嘌呤致大鼠慢性肾衰竭的实验研究"(F15-139-9-41)
关键词
益肾排毒方
肾纤维化
转化生长因子-β1
Yishen PaMu decoction
renal fibrosis
transforming growth fator-β1
