摘要
目的分析文献报道的乙型肝炎疫苗接种相关异常反应(Adverse events following immunization,AEFI)的一般规律及特点。方法用中文数据库检索15年来国内文献报道的乙型肝炎疫苗接种相关(疑似)AEFI病例,并进行分类统计、分析。结果乙型肝炎疫苗接种相关(疑似)AEFI的临床表现主要为过敏反应(41.13%),重组酿酒酵母乙型肝炎疫苗接种相关(疑似)AEFI病例所占比例最高(48.39%);多发生于接种后0.5～24h(35.48%)、接种后第2针(37.90%)及1岁以内的接种对象(49.19%)。结论乙型肝炎疫苗接种相关(疑似)AEFI总病例数较以往文献报道增加,但尚不能得出乙型肝炎疫苗相关(疑似)AEFI比例增多的结论,还需进一步更准确地研究分析。
Objective To analyze the regularity and characteristics of （suspected）adverse events following immunization （AEFI）of hepatitis B （HB）vaccine reported in documents. Methods Based on CNKI Chinese database retrieval system, all cases of AEFI associated with the HB vaccine in the past 15 years were collected and analyzed by categorical statistics. Results The clinical manifestations of（suspected）AEFI of HB vaccine were mainly allergic reactions（41. 13%）. The maximum percentage（48. 39%） of （suspected）AEFI cases were induced by recombinant HB vaccine （Saccharomyces cerevisiae）. The percentages of（suspected） AEFI cases appeared 0. 5 ～ 24 h after immunization, after the second dose and at ages of less than one year were 35. 48%, 37. 90% and 49. 19% respectively. Conclusion The total case number of （suspected）AEFI of HB vaccine increased as compared with that reported previously in documents. However, it could not be concluded that the percentage of AEFI case increased, which should be further analyzed accurately.
出处
《中国生物制品学杂志》
CAS
CSCD
2010年第10期1087-1089,共3页
Chinese Journal of Biologicals
基金
国家艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX10002-002)
人力资源和社会保障部2009年度留学人员科技活动择优资助项目
