摘要
目的:探讨银屑病患者血清和皮肤中基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)水平的临床意义。方法:寻常型银屑病患者22例,健康对照组15例。采用ELISA法检测两组血清MMP-2、MMP-9,皮肤MMP-2、MMP-9表达,采用免疫组化ABC法。结果:银屑病患者血清、皮肤中MMP-2、TIMP-9表达水平显著高于健康对照组(P<0.05)。结论:MMP-2、MMP-9增高可能是银屑病的发病机制之一。
Objective：To explore the role of matrix metalloproteinases（MMP） in the mechanism of psoriasis.Methods：MMP-2 and MMP-9 in the sera and skin lesions from 22 patients with psoriasis vulgaris were detected by ELISA and ABC methods,respectively.Other 15 healthy subjects served as controls.Results：Both serum and tissue MMP-2 and MMP-9 were increased in psoriasis patients as compared with those in controls（P〈0.05）.Conclusion：Elevated MMP-2 and MMP-9 may involve in the pathological progress of psoriasis.
出处
《浙江中西医结合杂志》
2010年第11期671-672,共2页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
