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基质金属蛋白酶-2、9在喉鳞状细胞癌患者血清中的表达 被引量:1

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摘要 目的探讨基质金属蛋白酶(MMP)-2、9在喉鳞状细胞癌(LSCC)患者血清中的表达水平及与临床特征的相关性。方法采用SDSPAGE Zymography法检测56例LSCC患者及40例正常对照组血清中MMP-2、MMP-9水平。结果喉癌患者血清MMP-2、MMP-9浓度明显高于正常对照组(P<0.05),其血清MMP-2、MMP-9浓度升高与淋巴结转移显著相关(P<0.05),与肿瘤原发部位、病理分级无明显相关性(均P>0.05)。血清MMP-9浓度与肿瘤临床分期无明显相关性。血清MMP-2浓度在T4期中明显升高,与其他分期之间差异显著(均P<0.05)。结论血清MMP-2、MMP-9在喉癌患者中的浓度明显升高,有助于喉癌的诊断;可能对预测淋巴结转移具有一定作用,并可成为喉癌手术方案选择的依据。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第14期3938-3939,共2页 Chinese Journal of Gerontology
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