摘要
目的:观察天智颗粒对美多芭诱导的大鼠多动症行为学的影响。方法:采用大剂量美多芭(360mg·kg-1·d-1)诱导大鼠多动症,考察天智颗粒(5g·kg-1·d-1)对模型大鼠游泳、刻板行为和肢体运动功能障碍的影响。结果:与模型组比较,天智颗粒组游泳、刻板行为和肢体运动功能障碍均获明显改善。结论:天智颗粒对大剂量美多芭诱导的多动症具有明显疗效,提示其对多巴胺替代疗法减毒增效的良好前景。
Objective：To explore the effects of Tianzhi Granules on Madopa-induced hyperkinesis in rats.Methods：To induce hyperkinesis with a large dose Madopa（360mg·kg^-1·d^-1）in rats and to investigate the effects of Tianzhi Granules on swimming,stereotypy locomotor and motor function of limbs in model rats.Results：Compared to model group,Tianzhi Granules group saw significant ameliorations in swimming,stereotypy locomotor and motor function of limbs.Conclusions：Tianzhi Granules produced potent therapeutic effects on large dose of Madopa-induced hyperkinesis,showing its bright promise in toxicityreducing and action-enhancing effects on dopamine replacement therapy.
出处
《辽宁中医药大学学报》
CAS
2010年第10期95-96,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
帕金森病
美多芭
多动症
天智颗粒
Parkinson＇s disease
Madopa
hyperkinesis
Tianzhi Granules
