摘要
强直性脊柱炎（ankylosing spondylitis,AS）是一种主要侵犯中轴关节的慢性炎症性自身免疫性疾病,致病机理复杂,具高度遗传倾向。迄今为止发病机制不明确,既往的研究报道HLA-B27基因与AS的发病强关联,但是HLA-B27阳性的人中只有不足10%发展为AS。大量研究提示除HLA-B27基因外,在非HLA区域同样存在AS的易感基因。近年来在非HLA区域发现了很多新的易感基因,本文就近年来与AS遗传易感性研究方法和非HLA区域易感基因的研究现状做一综述。
Ankylosing spondylitis（AS） is a chronic inflammatory autoimmune disease which violates mainly axial skeleton,Its patho-genic mechanism is very complex,with a high degree of genetic predisposition.To date the pathogenesis remains unclear.Past study re-ported that HLA-B27 gene and the occurrence of AS strongly correlate,but the B27-positive people were in less than 10% of the devel-opment of AS.A large number of research suggest that in addition to HLA-B27 gene,in the HLA region may still exist other susceptibili-ty genes,but this can only interprete in addition to about 50% of genetic susceptibility,so presumably susceptibility genes also exist in non-HLA region.In the non-HLA region in recent years a lot of new susceptibility genes were found.This article focuses on research methods in recent years,and research progress in AS susceptibility and non-HLA region susceptibility genes.
出处
《安徽医药》
CAS
2010年第10期1120-1122,共3页
Anhui Medical and Pharmaceutical Journal
基金
国家自然科学基金资助项目(No30771849,30972530)
安徽省自然科学基金资助项目(No090413133)
安徽省财政厅年度计划资助基金(No2009)
关键词
强直性脊柱炎
易感基因
遗传学
ankylosing spondylitis
susceptibility genes
genetics
