摘要
目的综合分析Matrilin-1基因rs1149048单核苷酸多态性(SNP)与青少年特发性脊柱侧凸(AIS)易感性的关系。方法计算机检查Medline、Cochrane图书馆、Ovid、Wiley Online图书馆、EBSCO、Elsevier Science Direct、Springer、CBM、CNKI、万方、维普等数据库,查询关于Matrilin-1 rs1149048 SNP与AIS易感性的病例对照文献,利用Revman 5.3和Stata12.0软件分析相关数据。结果最终共有4篇文献纳入。结果显示GG基因型[OR=1.21,95%CI(0.93,1.56),P=0.15]、AA基因型[OR=0.92,95%CI(0.75,1.13),P=0.44]与AIS易感性无关联性,G等位基因[OR=1.12,95%CI(1.01,1.24),P=0.03]、A等位基因[OR=0.89,95%CI(0.80,0.99),P=0.03]与AIS易感性有关联性。仅GG基因型有明显异质性(P=0.10,I2=52%),剔除来自日本的研究后,异质性降低(P=0.19,I2=41%),结果发生明显变化[OR=1.39,95%CI(1.10,1.75),P=0.005],提示该研究为异质性来源之一。纳入文献仅4篇,发表偏倚未评估。结论 Matrilin-1 rs1149048 G和A等位基因与AIS的易感性有关联性,G等位基因携带者对AIS的易感性增高。
Objective To investigate the association between rs1149048 polymorphism of Matrilin-1 gene and the susceptibility to AIS by a meta -analysis.Methods Case-control studies were searched from Medline,Cochrane Library,Ovid,Wiley Online Library,EB-SCO,Elsevier Science Direct,Springer,CBM,CNKI,Wan Fang and Wei Pu databases for the association between Matrilin-1 rs1149048 polymorphisms and the susceptibility to AIS.Meta -analysis was performed by Revman 5.3 and Stata 12.0 software.Pooled odds ratio (OR)with 95% confidence interval(CI)were derived from random -effects or fixed -effects models to assess the strength of the asso-ciation.Results Four case -control studies were included in the final meta -analysis.No statistically significant differences between AIS and controls group were observed between the susceptibility to AIS and Matrilin-1 rs1149048 genotype GG [OR =1.21,95%CI (0.93,1.56),P =0.15]and AA [OR =0.92,95%CI(0.75,1.13),P =0.44];however,significant differences in allele G [OR =1.12,95%CI(1.01,1.24),P =0.03]and allele A [OR =0.89,95%CI(0.80,0.99),P =0.03]were observed between AIS and control groups.There was obvious heterogeneity among the studies in Genotype GG(P =0.10,I2 =52%),sensitivity analysis performed by omitting one study at a time.When a Japanese study was omitted,the heterogeneity decreased(P =0.19,I2 =41%),and the pooled results were statistically significant [OR =1.39,95%CI(1.10,1.75),P =0.005],indicating that it might be a source of heterogenei-ty.Because there were only four studies included,the assessment of publication bias was not performed.Conclusions This meta -a-nalysis reveals that alleles G and A of Matrilin-1 rs1149048 are associated with the susceptibility to AIS.G -allele carriers have higher susceptibility.
出处
《安徽医药》
CAS
2015年第10期1933-1936,共4页
Anhui Medical and Pharmaceutical Journal
