摘要
目的:评价预防性使用抗生素对治疗急性坏死性胰腺炎(acute necrotizing pancreatitis,ANP)的作用.方法:在Medline、PubMed、Springer、Ovid、Elsevier、Embase、CNKI、维普数据库中,检索1994-01/2011-10发表的文献.按入选标准,最终纳入5篇文献,使用RevMan5.1进行统计分析.结果:预防性使用抗生素治疗急性坏死性胰腺炎与对照组相比,并不能显著改善生存率(RR0.75,95%CI0.43-1.28,P=0.29),也不能降低胰腺感染(RR0.81,95%CI0.55-1.19,P=0.29)、胰外感染(RR0.79,95%CI0.59-1.06,P=0.12)及手术干预(RR0.78,95%CI0.45-1.36,P=0.37)等并发症的发生几率.结论:对于预防性使用抗生素治疗急性坏死性胰腺炎,根据现有的随机对照治疗尚不能说明其可以显著降低病死率和减少并发症的发生.
AIM：To evaluate the role of prophylactic antibiotics in the management of acute necrotizing pancreatitis.METHODS：A computerized literature search of Medline,PubMed,Spring,Ovid,Elsevier,Embase,CNKI,and VIP databases was conducted to identify relevant articles published from January 1994 to October 2011.According to the inclusion criteria,5 studies were selected.The data were analyzed using RevMan 5.1 software.RESULTS：Our meta-analysis suggests that prophylactic antibiotic treatment did not significantly reduce morbility （RR=0.75,95%CI 0.43-1.28,P=0.29） or the incidence of infected pancreatic necrosis （RR=0.81,95%CI 0.55-1.19,P=0.29）,nonpancreatic infection （RR=0.79,95%CI 0.59-1.06,P=0.12）,or surgical intervention （RR=0.78,95%CI 0.45-1.36,P=0.37）.CONCLUSION：Prophylactic antibiotic treatment does not reduce the occurrence of infected pancreatic necrosis,nonpancreatic infection,surgical intervention or morbility in patients with acute necrotizing pancreatitis.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第14期1246-1251,共6页
World Chinese Journal of Digestology
关键词
预防性抗生素
随机对照
急性坏死性胰腺炎
Prophylactic antibiotics
Randomized controlled trials
Acute necrotizing pancreatitis
