摘要
随着分子生物学及生物技术的迅速发展,近年来基因治疗的基础研究与应用得到了长足进步。超声靶向破坏微泡(UTMD)是一种靶向、高效、有广阔应用前景的非病毒基因输送技术,其通过诱发细胞膜声孔作用,增加膜通透性,进而有效促进大分子物质的胞内传输,且可避免其他基因传输方法的不良反应。本文对UTMD介导基因或药物传递的应用领域予以综述。
With rapid development of techniques in molecular biology, the progress of gene therapy which is mainly dependent on the development of the methods of gene delivery has promoted. Among non-viral techniques, ultrasound-targeted microbubble destruction （UTMD） is considered as a new method with fewer side effect for organ-specific gene delivery in vitro and in vivo targeting delivery, which can stimulate the micromoleculer transferring into cells efficiently and lay a foundation for cancer gene therapy. The application fields of UTMD mediated gene or drug delivery was reviewed in this article.
出处
《中国医学影像技术》
CSCD
北大核心
2010年第9期1790-1792,共3页
Chinese Journal of Medical Imaging Technology
基金
广东省医学科研基金立项课题(A2010270)
关键词
超声检查
微泡
基因转移技术
基因治疗
Ultrasonography
Microbubble
Gene transfer techniques
Gene therapy
