摘要
采用新生大鼠胰岛离体培养方法，观察了五肽胃泌素（Ｇ－５）对ＩＬ－１Ｂ致胰岛Ｂ细胞分泌抑制的影响。结果表明：（１）ＩＬ－１Ｂ能剂量依赖性抑制Ｂ细胞的分泌功能；（２）Ｇ－５能对抗ＩＬ－１Ｂ对Ｂ细胞功能的抑制，与单纯ＩＬ－１Ｂ作用组相比，加用Ｇ－５能使葡萄糖刺激的胰岛素分泌量明显增加：（３）向ＩＬ－１Ｂ作用后的胰岛治疗性地给予Ｇ－５．能使抑制的Ｂ细胞功能得到部分恢复，作用呈时间和剂量依赖性。
The effect of pentagastrin (G-5) on interleukin-1B(IL-lB) inhibited insulin secretion in culturednewborn rat islet B-cells were observed. The results showed that IL-lB dose-dependently inhibitedboth glucose-stimulated and basal insulin secretion . The inhibitory effect of IL-1B was antagonizedwhen G-5 was given togather with IL-lB simultaneously. Glucose-stimulated insulin secretion of G-5 treated groups were significantly higher than those treated with IL-1B alone . In IL-1B treated islets ,adminstration of G-5 partially reversed the inhibition of insulin secretion in a dose and time dependentmanner.The results indicate that G-5 might have a protective effect against the toxicity of IL-lB onisolated islet B-cells .
出处
《基础医学与临床》
CSCD
1999年第2期78-80,共3页
Basic and Clinical Medicine
基金
河南省卫生厅科研基金
