摘要
目的 观察Graves病 (GD)患者外周血白细胞介素1β(IL -1β)的变化。方法 应用酶联免疫吸附试验 (ELISA法 )检测30例GD患者用丙基硫氧嘧啶治疗前后外周血中IL-1β 的含量。结果 治疗前GD患者外周血中IL-1β 含量高于正常对照组 ,而治疗后下降不明显。IL-1β 与患者游离甲状腺素 (FT3、FT4)、甲状腺球蛋白抗体 (TGAb)、甲状腺过氧化物酶抗体 (TPOAb)检测结果均无相关性。 结论 GD患者IL-1β 有改变。
Objective To investigate the serum cytokine IL-1βlevels in the Graves'disease(GD). Methods Serum IL-1βwas detected by enzyme-linked immunosorbent assay(ELISA)in30cases of GD before and after propylthiouracil(PTU)treatment and32cases of normal controls.Results The levels of serum IL-1βwere significantly elevated in patients with GD than that in control subjects(P<0.001)and were not decreased after PTUtreatment.There were no correlations of IL-1βwith FT 3 ,FT 4 ,TGAb and TPOAb.Concl_ usion Serum cytokine IL-1βmay be associated with the pathogenesis of Graves'disease.
出处
《浙江医学》
CAS
2003年第12期723-724,共2页
Zhejiang Medical Journal
