摘要
目的探讨CD44v6和MMP-9蛋白在食管鳞癌发生、发展、浸润和转移过程中的表达、作用及两者相关性。方法采用免疫组化法检测73例食管鳞癌组织和其癌旁正常食管黏膜组织中CD44v6和MMP-9蛋白的表达,探讨两者与食管鳞癌临床病理特征的关系。结果 CD44v6和MMP-9蛋白在73例食管鳞癌组织中呈明显高表达,在正常食管黏膜组织中低表达,差异有统计学意义(P<0.05);CD44v6和MMP-9蛋白表达与食管鳞癌的分化程度、肿瘤浸润深度、淋巴结转移有关(P<0.05);食管鳞癌癌组织中CD44v6和MMP-9蛋白的表达呈正相关(r=0.397,P<0.05)。结论 CD44v6和MMP-9蛋白在食管鳞癌组织中呈高表达,两者可能共同参与了食管鳞癌的发生、发展、浸润和转移过程。
Objective To investigate the expressions of CD44v6 and MMP-9 in human esophagus squamous cell carcinoma tissues and their matched normal mucosa tissues,then study the relationship between the expressions of CD44v6 and MMP-9 and the tumor of invasion and metastasis.Methods The expressions of CD44v6 and MMP-9 were detected by immunohistochemistrical method in 73 cases of human esophagus squamous cell carcinoma and matched normal mucosa tissues.Results Compared with the normal esophageal mucosa,the expressions of CD44v6 and MMP-9 were significantly over-expressed in human esophagus squamous cell carcinoma tissues（P〈0.05）.The difference of the expressions of CD44v6 and MMP-9 in human esophagus squamous cell carcinoma of different histological types,different infiltrative depth and lymph node metastasis was significant（P〈0.05）.Significantly positive correlation was found between the expressions of CD44v6 and MMP-9（r=0.397,P〈0.05）.Conclusion The protein of CD44v6 and MMP-9 might play an important role in the progression of the malignant transformation,invasion and metastasis of human esophagus squamous cell carcinoma,and they might serve as predicting factors for this disease.
出处
《肿瘤基础与临床》
2010年第3期195-198,共4页
journal of basic and clinical oncology
