摘要
目的探讨MMP-9在胰腺癌组织中的表达及其与临床病理因素的关系。方法采用免疫组织化学技术检测73例胰腺癌、37例胰腺正常组织中MMP-9蛋白的表达,并对其与临床病理因素的关系进行相关性分析。结果胰腺癌与正常胰腺组织MMP-9蛋白表达阳性率差异有统计学意义,分别为65.75%和10.81%(P<0.05)。胰腺癌组中,中高分化病例MMP-9蛋白表达阳性率为45.45%,低分化病例为74.51%,二者比较,差异有统计学意义(P<0.05);A+B期病例MMP-9蛋白表达阳性率为43.59%,明显低于C+D期(91.18%)(P<0.05);≤60岁病例MMP-9蛋白表达阳性率为59.52%,>60岁病例阳性率为74.19%,二者比较差异无统计学意义(P>0.05)。结论MMP-9蛋白的表达在胰腺癌组织中明显增高,且与其组织分化、临床分期有关,与患者年龄大小无关。MMP-9蛋白表达与胰腺癌的发生发展密切相关,在胰腺癌的诊断方面可能是比较好的协助诊断分型、判断预后因子。
Objective To investigate the expression of MMP-9 in pancreatic cancer,and to explore its relations with clin- icopathological factors. Methods Immunohistochemistry was used to detect the expression of MMP-9 in 73 cases of pan- creatic cancer, and 37 cases of normal pancreas. Results The positive rate of MMP-9 had significant difference between patients with pancreatic cancer and normal pancreas （P 〈 0.05）. The expression of MMP-9 was correlated with grade and stage of pancreatic cancer （P 〈 0.05）, but not to age of onset IP 〉 0.05）. Conclusion The expression of MMP-9 may play a role in the tumorigenesis and progression of pancreatic cancer. MMP-9 could be a factor to diagnose the typing of pancre- atic cancer and predict the prognosis of pancreatic cancer.
出处
《中国现代医生》
2012年第14期155-156,共2页
China Modern Doctor
关键词
胰腺癌
免疫组化
MMP-9
Pancreatic cancer
Immunohistochemistry
MMP-9
