摘要
目的观察鹿衔草总黄酮对大鼠急性心肌缺血心电图变化的影响和抗心肌缺血作用机制。方法静脉注射垂体后叶素造成大鼠急性心肌缺血模型,记录心电图变化;另结扎大鼠冠状动脉,记录结扎后心电图变化,同时用分光光度法测定冠脉结扎大鼠血清一氧化氮(NO)及游离脂肪酸(FFA)含量。结果鹿衔草总黄酮对抗垂体后叶素及结扎冠脉诱发的急性心肌缺血大鼠心电图T波的降低,升高冠脉结扎大鼠血清NO含量,降低血清FFA含量。结论鹿衔草总黄酮对大鼠急性心肌缺血具有保护作用,其作用可能与增加NO的释放和降低FFA有关。
Objective To investigate the effect of total flavonoid of Herba Pyrolae（TFHP） on the changes of ECG in rats with acute myocardial ischemia as well as the mechanism of the action.Methods Acute myocardial ischemic model was established by intravenous injection of pituitrin in rats,and ECG was recorded.Acute myocardial infarction model was established by the ligation of left descending coronary artery in rats,and serum level of nitric oxide（NO） and free fatty acid（FFA） was determined with spectrophotometrical method besides ECG.Results In comparison with the model controls,TFHP antagonized the decreased T wave by pituitrin and ligating coronary artery,and increased NO level and reduced FFA concentration in the serum of rats with acute myocardial ischemia.Conclusion TFHP protects the myocardium from ischemic injury possibly through increasing NO release and decreasing FFA production.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第5期581-583,630,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
关键词
鹿衔草总黄酮
心肌缺血
一氧化氮
游离脂肪酸
total flavonoids of Herbal Pyrola
myocardial ischemia
nitric oxide（NO）
free fatty acid（FFA）
