摘要
目的:观察蛇床子素内酯环完整性对其抑临床常见浅部真菌活性的影响。方法:配制pH=4和pH=9的蛇床子素溶液,以K-B法比较其对须毛癣菌、红色毛癣菌和石膏样小孢子菌的抑菌活性。结果:在pH=4和pH=9时对三种真菌的抑菌圈直径对比分别为32mm∶22mm(P<0.01)、35mm∶37mm(P>0.05)和31mm∶29mm(P>0.05)。结论:蛇床子素内酯环开环前对三种真菌均表现出较好抑菌活性,开环后对须毛癣菌抑菌活性消失,但对石膏样小孢子菌和红色毛癣菌则没有影响。
Objective：To observe the effect on superficial mycosis of the integrality of ostholes lactonic ring.Methods：Prepared the osthole solutions of pH=4 and pH=9,compared antifungal activity to T.mentagrophytes,T.purpureatum,and Microsporum gypseum by Kirby-Bauer method.Results：The Diameter of inhibition zone of pH=4 compared to that of pH=9 in three funguses were 32 mm∶22 mm（P0.05）,35 mm∶37 mm（P0.05） and 31 mm∶29 mm（P0.05）.Conclusion：Osthole with integrated lactonic ring had antifungal activity to three funguses.When lactonic ring was broken antifungal activity to T.mentagrophytes disappeared,but no difference was observed to T.purpureatum,and Microsporum gypseum.
出处
《中国医药导报》
CAS
2010年第24期20-21,共2页
China Medical Herald
基金
广东省中医药局资助课题(编号:2007196)
