摘要
目的：探讨建立动力型肺动脉高压（ＰＨ）的方法及途径．方法：利用同种异体成年犬左锁骨下动脉，在幼犬降主动脉与左下肺动脉之间搭桥，造成降主动脉向左下肺动脉分流，建立幼犬动力型单侧ＰＨ模型．结果：该模型分流后３ｍｏ左下肺动脉收缩压（１１．１３±１．５１）ｋＰａ，［分流前为（１．３６±０．３２）ｋＰａ，Ｐ＜０．００１］，左下肺动脉收缩压／体动脉收缩压力比值为０．６７（分流前为０．１３，Ｐ＜０．００１），肺动脉压显著增高，光镜及硫酸钡肺动脉灌注造影显示肺动脉内膜增生，中层肥厚．部分肺动脉阻闭．结论：该模型产生的血流动力学特征明显，全组成活率高，适于基础及临床研究用．
AIM: To set up a model of unilateral dynamic pulmonary hypertension(PH). METHODS: Using left subclavian artery from homologous adult dogs, a shunt from descending aortatolower left pulmonary artery was created in juvenile dogs. RESULTS: The lower left pulmonary artery pressure was 11.131.51 kPa 3 months postshunt, compared with 1.360.32 kPa of preshunt (P<0.001), and the ratio of the lower left pulmonary systolic pressure to systemic artery systolic pressure was 0.67 compared with 0.13 preshunt partial. There was a significant increase of pulmonary artery pressure (P<0.001). Morphometric analysis of microscope and the sulfate bariumfilled pulmonary artery contrast revealed intimal hyperplasia, medial hypertrophy and partial obliteration in pulmonary arteries . CONCLUSION: The model established is of remarkable hemodynamic characteristics with high survival rate, and is suitable for both preclinical and clinical studies of PH.
出处
《第四军医大学学报》
1999年第4期328-330,共3页
Journal of the Fourth Military Medical University
关键词
肺动脉高压
动物模型
犬
hypertension
pulmonary
animal
model
