摘要
目的观察慢性阻塞性肺疾病（COPD）合并肺栓塞（PE）时凝血指标及肺动脉收缩压（SPAP）的变化。方法选择2010年6月至2012年6月在郑州大学第一附属医院住院的COPD患者200例，其中单纯COPD164例，COPD合并肺栓塞36例；选择健康体检者50例为对照组。应用免疫比浊法测定凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（Tr）、纤维蛋白原（Fbg），采用ELISA方法测定D-二聚体（D．D），超声心动图测定SPAP。结果COPD患者1vr及APlvI’缩短，1Tr延长，Fbg及D-D增加，SPAP增高；COPD合并肺栓塞者较单纯COPD者APl盯明显缩短，Fbg增加，D-D增加，SPAP增高。结论COPD合并肺栓塞时存在高凝状态及纤溶亢进，其肺动脉收缩压力较单纯COPD患者显著增高。
Objective To Observe the changes of coagulation index and systolic pulmonary ar- tery pressure （SPAP） in patients with chronic obstructive pulmonary disease（COPD） combined with pul- monary embolism （PE）. Methods Two hundred patients who were hospitalized in the first affiliated hos- pital of Zhengzhou university between June 2010 to June 2012 were selected, there were 164 patients with simple COPD and 36 patients with COPD combined with PE. Fifty healthy controls were selected as the control group. Prothrombin time （ PT）, activated partial thromboplastintime （ APTT）, thrombittime （ TT）, fibrinogen （Fbg） were determined with immunoturbidimetry, D-dimer （D-D） were determined with ELISA, and the systolic lung artery pressure were determined by colour doppler ultrasound. Results Compared with the simple COPD patients, the Fbg, D-D, SPAP of patients with COPD combined with PE were higher, APTI＂ was shorter. Conclusions Patients with COPD combined with PE had hypercoag- ulable state and hyperfibrinolysis, and the systolic pulmonary artery pressure was higher than that of sim- ple COPD patients.
出处
《中国实用医刊》
2013年第10期37-38,共2页
Chinese Journal of Practical Medicine
关键词
慢性阻塞性肺疾病
肺栓塞
凝血指标
肺动脉收缩压
Chronic obstuctive pulmonary disease
Pulmonary embolism
Coagulation index
Systolic pulmonary artery pressure
