摘要
目的:观察白屈菜水提取物(WECM)的镇痛作用,并初步探讨其镇痛作用与阿片受体的关系,为其临床应用提供依据。方法:采用小鼠扭体法、热板法、观察WEHC的镇痛作用及纳络酮对其镇痛作用的影响,探讨其镇痛作用与阿片受体的关系。结果:WEHC明显减少腹腔注射酒石酸锑钾引起的小鼠扭体反应次数,与盐水对照组比较差异显著(P<0.01)、提高55℃热板法致小鼠疼痛反应的阈值,与盐水对照组比较差异显著(P<0.01),其镇痛作用不被纳络酮所拮抗。结论:白屈菜水提取物有明显的镇痛作用。其镇痛作用不是由吗啡受体介导的。
Objective：To investigate the analgesic effect of water extrat of Herba Chelidonii （WEHC） and priliminary explore the relationship between analgesic effect of WEHC with opium acceptor.Methods：The writhing and hot plate test of mice were adopted to evaluate analgesic effect of WEHC. The effect of naloxone on analgesic action of WEHC was observe to explore the relationship between analgesic effect of WEHC with the opioid receptor.Results：In the writhing test,WEHC significantly reduced the number of writhing induced by ip 0.05% antimony potassium tartrate, in the hot plate test,WEHC significantly enhanced pain threshold value induced by thermal stimulation.Naloxone had no effect on analgesic action of WEHC.Conelusion：WEHC has significant analgesic effect and its analgesic effect is not mediated by opium acceptor.
出处
《中国医药导刊》
2010年第6期1016-1017,共2页
Chinese Journal of Medicinal Guide
关键词
白屈菜
水提取物
镇痛
纳络酮
Herba Chelidonii
Water extract
Analgesic effect
Naloxone
Opiun acceptor
