摘要
目的探讨三维适形放射治疗(3D-CRT组)与常规放疗(CF组)治疗食管癌的疗效及放射反应。方法采用3D-CRT方法治疗食管癌60例(3D-CRT组,2.0Gy～2.5Gy/次,5次/周,共治疗24～30次,总剂量60Gy,整个疗程35～42d),与同期行常规放射治疗的60例食管癌(CF组,2.0Gy/次,5次/周,共治疗32～35次,总剂量64～70Gy,44～49d)进行比较。结果近期疗效CF组和3D-CRT组甲级、乙级、丙级分别为27例、18例、15例和35例、23例、2例。CF组和3D-CRT组1,2,3年局部控制率分别为58.0%,49.1%,40.2%和74.3%,63.1%,46.5%(χ2=4.738P=0.029<0.05)。CF组和3D-CRT组放射治疗后1,2,3年生存率分别为53.2%,44.1%,33.7%和68.0%,57.8%,45.1%(χ2=6.472,P=0.011)。3D-CRT组放射性食管炎及放射性气管炎发生率均较CF组略高,血液系统及全身反应3D-CRT组较CF组轻。结论 3D-CRT能明显改善食管癌的近期疗效、局部控制率和生存率,近期放射反应及远期放射损伤均可耐受。
Objective To evaluate the results and side effects in three dimensional conformal radiation therapy （3D-CRT） or Conventional Radiation （CF） for esophageal carcinoma.Methods From May 2006 to October 2009,60 patients with esophageal carcinoma were treated with 3D-CRT （3D-CRT group）,in which all the case were treated once every day to a total dose of 60 Gy in 35～42 days at 2.0～2.5Gy per fraction totally 24～30 fractions,and during the same period,other 60 patients treated by conventional fractionation radiotherapy （CF group） to a total dose of 64～70 Gy over 44～49 days at 2.0Gy per fraction 5 days perweek were analyzed and compared.Results The near future therapeutic effect of first、second、third rates in CF group were 27 examples,18 examples,15 examples and compared with 35 examples,23 examples,2 examples in 3D-CRT group.The 1,2,3years local control rates in CF group were 58.0%,49.1%,40.2% compared with 74.3%,63.1%,46.5%（χ2=4.738,P=0.0290.05） in 3D-CRT group.And the survival rates in 1,2,3years in CF group were 53.2%,44.1%,33.7% as compared with 68.0%,57.8%,45.1%（χ2=6.472,P=0.011） in 3D-CRT group.However,in the 3D-CRT group,the incidence of acute radiation esophagitis or tracheitis as higher and those of hematogenous side effects and body symptom were lower.Conclusions Compared with conventional fractionation radiotherapy,3D-CRT was able to improve the local control rate of esophageal carcinoma,with tolerable acute and late radiation side effects.
出处
《四川医学》
CAS
2010年第7期937-939,共3页
Sichuan Medical Journal
关键词
食管癌
放射治疗
常规
三维适形
预后
esophageal carcinoma
radiotherapy
conformal
prognosis
