摘要
目的利用64排螺旋CT(64multi-detector computed tomography,64-MDCT)初步评价北京社区人群的冠状动脉钙化(coronary artery calcium,CAC)情况。方法对北京地区社区人群进行抽样研究,利用64-MDCT(GE,LightSpeed VCT)对1480例研究对象进行冠状动脉钙化扫描,应用Agatston积分法分别计算其冠状动脉钙化积分(coronary artery calcium score,CACS),观察CAC分布特征,以性别及年龄分组比较组间的CAC差别。结果总样本CAC阳性率为29.9%;男性组的CAC阳性率为37.6%,明显高于女性组的23.1%(P<0.01)。同一性别各年龄组的CACS均呈正偏态分布,CAC阳性率和CACS均随年龄增加而显著增高(P<0.01);40～、50～岁组的CAC阳性率以及40～、50～、60～岁组的CACS存在性别间的显著性差异。1480例研究对象有206例(13.9%)为单支钙化,237例(16.0%)为多支钙化;总样本共5920支冠状动脉中以前降支(26.8%)及右冠状动脉(13.5%)钙化阳性率为高(P<0.01)。结论 64-MDCT能够方便、快速地量化检测社区人群的CAC的发病情况,评价人群中的CAC分布特征及规律,从而初步判定人群中的冠状动脉粥样硬化病变的流行病学特征。
Objectives To initially evaluate coronary artery calcium （CAC） characteristics of the community population in Beijing with 64 multi-detector computed tomography （64-MDCT）.Methods Totally 1 480 cases random sampling from the community population in Beijing were performed coronary calcium scan with 64-MDCT （GE,LightSpeed VCT）.Coronary artery calcium score（CACS,Agatston score） was calculated respectively.The characteristics and difference of CAC and CACS was compared between groups of gender and age.Results The positive rate of CAC in total sample was 29.9%;the positive rate of CAC in male group was 37.6%,significantly higher than the 23.1% in female group（P〈0.01）.In each age group of gender,the CACS was a positively-skewed distribution.In each gender group,positive rate of CAC and CACS increased with age respectively（P〈0.01）;the CAC positive rate in age groups of 40-,50- and the CACS in age groups of 40-,50-,60- years had significant difference between gender groups.In 1 480 cases,206（13.9%） have single-vessel lesion,237（16.0%） have multiple-vessel lesion;the CAC positive rate of left anterior descending （26.8%）and right coronary artery （13.5%） were higher than those of other coronary arteries in the total 5 920 coronary arteries of the sample （P〈0.01）.Conclusions 64-MDCT can detect and quantify CAC easily and quickly,evaluate the CAC distribution and coronary atherosclerosis characteristics in community population.
出处
《岭南心血管病杂志》
2010年第2期99-102,137,共5页
South China Journal of Cardiovascular Diseases
基金
国家"十一五"科技支撑计划课题资助(项目编号:2007BAI05B02)
