摘要
目的调查狂犬病疫苗Essen(伊森)程序的依从性,并分析Essen程序和Zagreb(赞瑞博)程序的经济成本。方法对2007年6月～2009年1月,在北京大学人民医院急诊就诊的狂犬病暴露后处置的患者进行问卷调查,了解其对Essen接种程序的依从性;利用人民医院所用疫苗的均价和接种成本、2008年人均国民生产总值估算的生产力损失、中国药品生物制品检定所公布的2007～2009年年均狂犬病疫苗批签发量,估算Essen程序和Zagreb程序的经济学成本。结果共对3440例患者进行了疫苗接种依从性分析,Ⅰ、Ⅱ、Ⅲ级暴露患者全程接种疫苗的依从比例分别为33.3%、77.1%和78.0%,第三针之前的依从性较高,第四针之后显著下降。Essen程序和Zagreb程序的个人就医成本分别为694和482.2元;估算全国Essen程序就医成本为97.09亿元,Zagreb程序为67.46亿元。结论为合理应用狂犬病疫苗、简化接种程序、提高患者依从性、降低经济成本,应大力推广Zagreb接种程序。
Objective To learn the compliance status regarding completing full rabies vaccination schedule,and to analyse the economic cost.MethodsInterviewing patients who visited doctor at Emergency Department,the People＇s Hospital,Beijing University from June 2007 to January 2009 on vaccination compliance of Essen regimens.The economic cost of Essen regimen and Zagreb regimen were estimated using average vaccination cost,average release amount by National Institue for Control of Pharmaceutical and Biological Products.ResultsIn total,3440 patients were interviewed.The proportion completing full vaccine schedule was 33.3%,77.1% and 78.0% for exposure category I,II and III respectively.The compliance was high for first 3 doses,it reduced significantly after the third dose.The individual medical costs was 694 RMB for Essen regimen,and 482.2 RMB for Zagreb regimen.The estimated annual medical costs was 9.709 billion RMB for Essen regimen,and 6.746 billion RMB for Zagreb regimen nationaly.ConclusionsThe Zagreb regimen should be recommended in order to simplify the vaccine administration,to increase compliance and to reduce rabies vaccination cost.
出处
《中国疫苗和免疫》
CAS
2010年第3期254-257,共4页
Chinese Journal of Vaccines and Immunization
关键词
狂犬病疫苗
依从性
经济成本
Rabies vaccination
Compliance
Economic cost
