摘要
目的:测定反流性食管炎患者血浆血管活性肠肽(VIP)、胃动素浓度,及下食管括约肌压力(LESP),以探讨反流性食管炎的发病机制。方法:采用液体灌注体外传感器法测定28例反流性食管炎患者下食管括约肌压力。采用放射免疫法测定其血浆VIP及胃动素浓度。结果:病例组血浆VIP浓度与对照组差异有显著性(P<0.05)。LESP与血浆VIP浓度呈明显负相关(r=-0.912.P<0.01)。病例组血浆胃动素浓度与对照差异有显著性(P<0.05)。LESP与血浆胃动素浓度无相关性。结论:反流性食管炎患者存在胃肠激素异常,其中血浆VIP升高,胃动素降低。血浆VIP升高可降低LESP,而胃动素降低对LESP无影响。
Purpose: We measured the plasma concentration of vasoactive intestinal polypeptide(VIP), motilin and lower esophageal sphincter pressure(LESP) in patients with reflux esophagitis in order to evalu-ate the relationship between these factors and reflux esophagitis. Methods: Digestive fract manometry in-strument was used to measure LESP of 28 patients with reflux esophagitis. Radioimmunoassy technique was used to measure the plasma concentration of VIP, motilin. Result: The mean VIP plasma concentra-tion in 28 patients with reflux esophagitis was higher than the mean value in control ( P <0.01) . There was a significant correlation between LESP and VIP plasma level (r=-0.912, P< 0. 01). The mean motilin plasma concentration in patients was lower than the mean value in control ( P<0. 05 ) . There was not correlation between LESP and motilin plasma level. Conclusion: The patients with reflux esophagitis exist the hormonal abnormalities include the high plasma VIP level and low plasma motilin level. The high plasma VIP level reduce LESP. The low plasma motilin level has little effect to LESP.
出处
《临床消化病杂志》
1999年第1期9-10,共2页
Chinese Journal of Clinical Gastroenterology
关键词
反流性食管炎
血管活性肠肽
胃动素
病理
Reflux esophagitis Lower esophageal sphincter pressure Vasoactive intestinal polypep-tide Motilin
