摘要
目的使用修订后的中国人代谢综合征(MS)诊断标准,对MS及其组分与脑卒中关系进行探讨。方法收集脑卒中患者1068例,其中动脉粥样硬化性血栓性脑梗死(ATCI)男、女性亚组分别为283例和231例;腔隙性脑梗死(LACI)男、女性亚组分别为240例和176例;脑出血(ICH)男、女性亚组分别为76例和62例。健康体检者317例,男、女性亚组分别为147例和170例。观察MS及其组分在脑卒中及其亚型男、女性亚组和对照男、女性亚组的患病率、MS各组份水平以及MS对两性脑卒中及其亚型的危险度。结果除ICH男性亚组外,脑卒中及其亚型男、女性亚组MS的患病率(36.2%～45.2%)与同性别对照组(16.3%～19.4%)比较有显著性差异(P<0.01)。多因素Logistic回归分析显示,MS是男、女性脑卒中发病的危险因素(OR=2.486,OR=2.865;P<0.01),也是除男性ICH外的两性脑卒中各亚型发病的危险因素。在MS各组份中,高血压是两性脑卒中及其所有本研究涉及亚型发病的危险因素。结论 MS是两性脑卒中发病的重要危险因素;也是除男性ICH外的两性脑卒中各亚型发病的重要危险因素;在MS各组份中,高血压对两性脑卒中及其亚型的发病起最重要作用。
Objective To study the relationship between stroke and the metabolic syndrome （MS） defined based on criteria in Chinese population. Methods 1068 stroke patients （599 men and 469 women） were divided into atherothrom- botic cerebral infarction（ATCI） group （283 men and 231 women）, lacunar cerebral infarction（LACI） group （240 men and 176 women）, and intracerebral hemorrhage（ICH） group （76 men and 62 women） who fulfilled the diagnostic criteria of the China Guideline for Cerebrovascular Disease Prevention and Treatment. 317 control subjects （147 men and 170 women） without clinical signs of stroke were selected by detailed case history, physical examination and CT or MRI. The preva- lence and risk of MS were observed in stroke and its subtypes and control subjects. MS was defined by the modified crite- ria of Chinese population. Results The prevalence of MS in stroke and its subtypes was 36.2% to 45.2%. The prevalence of MS was significantly higher in stroke and its subtypes, except ICH in men compared with the control subjects （P 0.01）. Logistic regression analysis indicated that the odds ratio （confidence interval） associated with MS was 2.486（1.534~ 4.029） in men and 2.865（1.853~4.428） in women for stroke, 2.475（1.464~4.187） and 2.739（1.663~4.510） for ATCI, 3.125 （1.846~5.290） and 3.267 （1.970~5.416） for LACI, and 2.041 （1.040~4.007） in women for ICH. Among the components of MS, high blood pressure showed stronger impact on stroke and its subtypes in men and women. Conclusions MS is an important risk factor for stroke and its subtypes but not for ICH in men. The high blood pressure plays a key role in the occurrence of stroke and its subtypes in men and women.
出处
《北京医学》
CAS
2010年第7期511-515,共5页
Beijing Medical Journal
关键词
代谢综合征
脑卒中
高血压
危险因素
Metabolic syndrome
Stroke
High blood pressure
Risk factor
