摘要
目的:探讨颈动脉粥样硬化狭窄程度与幽门螺杆菌感染的关系。方法:选取2018年5月-2020年5月本院接受颈动脉超声检查且确诊为颈动脉粥样硬化的150例患者作为研究对象,依据病情程度的不同将其分为重度狭窄组、中度狭窄组及轻度狭窄组,各50例,并选择同期颈动脉正常人群50例作为对照组。通过酶联免疫吸附测定法检测所有研究对象的Hp抗体(Hp-IgG)、基质金属蛋白酶-9(MMP-9)以及脂蛋白相关磷脂酶A2(Lp-PLA2),并分析颈动脉粥样硬化狭窄程度同Hp感染的关系。结果:轻度、中度、重度狭窄组的Hp-IgG阳性率均高于对照组,差异均有统计学意义(χ^(2)=22.694、24.448、36.526,P<0.05);但轻度、中度、重度狭窄组两两比较,差异均无统计学意义(P>0.05)。Hp-IgG阳性组血清Lp-PLA2及MMP-9水平均高于Hp-IgG阴性组,差异均有统计学意义(P<0.05)。轻度、中度、重度狭窄组的血清Lp-PLA2、MMP-9水平均高于对照组,差异均有统计学意义(P<0.05);随着狭窄程度的加重,Lp-PLA2、MMP-9水平均逐渐升高,中度狭窄组的Lp-PLA2、MMP-9水平均高于轻度狭窄组,重度狭窄组的Lp-PLA2、MMP-9水平均高于中度狭窄组,差异均有统计学意义(P<0.05)。结论:颈动脉粥样硬化狭窄程度与幽门螺杆菌感染存在一定的关系,Hp感染后会通过升高炎症因子Lp-PLA2、MMP-9,增强局部炎症反应来加剧颈动脉粥样硬化狭窄程度。
Objective:To investigate the relationship between the degree of carotid atherosclerotic stenosis and Helicobacter pylori(Hp)infection.Method:A total of 150 patients with carotid atherosclerosis who received carotid artery ultrasound examination in our hospital from May 2018 to May 2020 were selected as the research subjects,and they were divided into severe stenosis group,moderate stenosis group and mild stenosis group according to the severity of the disease,with 50 cases in each group,50 patients with normal carotid artery were selected as the control group.The Hp antibody(Hp-IgG),matrix metalloproteinase-9(MMP-9)and lipoproteinassociated phospholipase A2(Lp-PLA2)of all subjects were detected by enzyme-linked immunosorbent assay,and the relationship between the degree of carotid artery atherosclerotic stenosis and Hp infection was analyzed.Result:The positive rates of Hp-IgG in the mild,moderate and severe stenosis group were higher than that in the control group,the differences were statistically significant(χ^(2)=22.694,24.448,36.526,P<0.05);however,pairwise comparison of mild,moderate and severe stenosis group showed no statistical significances(P>0.05).Serum Lp-PLA2 and MMP-9 levels in Hp-IgG positive group were higher than those in Hp-IgG negative group,the differences were statistically significant(P<0.05).Serum Lp-PLA2 and MMP-9 levels in the mild,moderate and severe stenosis group were higher than that in the control group,the differences were statistically significant(P<0.05);with the aggravation of stenosis,the levels of Lp-PLA2 and MMP-9 increased gradually,the levels of Lp-PLA2 and MMP-9 in the moderate stenosis group were higher than those in the mild stenosis group,and the levels of Lp-PLA2 and MMP-9 in the severe stenosis group were higher than those in the moderate stenosis group,the differences were statistically significant(P<0.05).Conclusion:There is a certain relationship between the degree of carotid atherosclerotic stenosis and Hp infection,after Hp infection,the degree of carotid atheros
作者
黄赞鸿
刘昱
林英奎
HUANG Zanhong;LIU Yu;LIN Yingkui(Dafeng Hospital of Chaoyang District in Shantou,Shantou 515154,China;不详)
出处
《中国医学创新》
CAS
2021年第18期115-119,共5页
Medical Innovation of China
