摘要
免疫耐受是机体对抗原的一种特殊免疫应答状态。在诱导耐受特别是在诱导外周T细胞耐受中,B细胞不仅可以分泌抗体及参与免疫调节,而且可以作为特异性的抗原提呈细胞起到重要作用。它可以活化T细胞导致免疫反应,也可以致T细胞耐受帮助诱导免疫耐受。认识B细胞如何诱导耐受可以为设计新的疗法调节自身免疫疾病和移植免疫中免疫耐受与免疫反应之间的平衡提供服务。
Immune tolerance is a special immune response state against antigen in body. In the induction of tolerance especially in the induction of peripheral T-cell tolerance, B cells which can not only secrete antibodies and be able to participate in immune regulation but also can do as specific antigen-presenting cells play an important role. B cells can activate T-cell leading to immune response and still can tolerize T-cell inducing immune tolerance. Understand how B-cell induce B-cell tolerance can be in service to the design of new therapies regulating the balance between immune tolerance and immune response in autoimmune diseases and trans- plantation immunity.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2010年第7期643-646,共4页
Immunological Journal
基金
国家自然科学基金(30772042)
关键词
B淋巴细胞
免疫耐受
抗原提呈
抑制因子
共刺激作用
B lymphocytes
hnmune tolerance
Antigen presentation
Inhibitive factor
Costimulation
