摘要
目的观察阿托伐他汀对急性脑梗死患者血清VEGF、IL-1β和TNF-α的影响,探讨阿托伐他汀对急性脑梗死脑保护作用机制。方法实验分为对照组和阿托伐他汀治疗组(低剂量组、高剂量组)。对照组和阿托伐他汀治疗组基础用药相同,阿托伐他汀治疗组选取治疗后2天、3天、5天、7天、10天、14天作为观察点。神经功能缺损程度评分(neurological deficiencyscore,NDS)和日常生活能力评分(activity daily living,ADL)评定临床治疗效果,采用酶联免疫吸附法检测急性脑梗死患者VEGF、IL-1β和TNF-α血清水平。结果经过阿托伐他汀治疗后与对照组比较NDS和ADL评分显著增高(P<0.05)。经过阿托伐他汀治疗后IL-1β和TNF-α血清水平均有不同程度下降,经过阿托伐他汀治疗后VEGF活性均有不同程度升高,低剂量组治疗1周后有明显变化(P<0.05),高剂量组治疗3天后明显变化(P<0.01)。结论阿托伐他汀能降低急性脑梗死血清IL-1β和TNF-α水平、增强VEGF活性,阿托伐他汀可以通过抑制急性脑梗死炎症反应和增强血管修复发挥脑保护作用。
ObjectiveTo investigate the effect of atorvastatin influences on serum level of VEGF, IL-1β and TNF-α in acute cerebral infarct patients,and to study neuroprotection mechanism of atorvastatin for acute cerebral infarct. MethodsAcute cerebral infarct patients were divided into control group and atorvastatin treatment groups（low-dose group, high-dose group）. The clinical measurement was introduced by Neurological deficiency score and Activity daily living. Serum level of IL-1β, TNF-α and VEGF was measured by enzyme linked immunosorbent assay. ResultsAfter atorvastatin treatment, serum level of IL-1β and TNF-α decreased and the expression of VEGF increased in acute cerebral infarct patients. These indicators changed significantly after one week treatment in Low-dose group （P〈0.05）, after three day treatment in high-dose group （P〈0.01）.ConclusionAtorvastatin can restrain the expression of IL-1β and TNF-α and increase the expression of VEGF in acute cerebral infarct patients. Atorvastatin can enhance recovery of vascular cognitive impairment to protect neural function by restraining neuroinflammation.
出处
《医学研究杂志》
2010年第6期82-84,共3页
Journal of Medical Research
关键词
急性脑梗死
阿托伐他汀
血管内皮生长因子
炎症
Acute cerebral infarct Atorvastatin Vascular endothelial growth factor Inflammation
