摘要
目的探讨高血压脑出血患者血清C-反应蛋白（CRP）及白介素-6（IL-6）的水平变化及其临床意义。方法选取2013年2月至2013年9月收治的高血压脑出血患者75例，根据出血量分成3组：小出血量组（出血量〈30ml，25例），中等量出血组（出血量为30-50ml，25例），大量出血组（出血量〉50ml，25例）。选择同期正常体检者42例作为对照组，比较各组患者血清CRP、IL-6的水平。结果高血压脑出血患者血清CRP水平[（8．35±0．92）mg／L]及IL-6水平[（23．26±2．09）pg/ml]明显高于对照组[分别为（3．17±0．54）mg／L、（4．26±0．69）pg／ml；P〈0．05]；随着脑出血量增多，CRP和IL-6血清水平均明显增高（P〈0．05）。出血后30d根据GOS评分评估患者预后，血清CRP和IL-6水平越低患者良好越好（P〈0．05）。结论高血压脑出血患者血清CRP及IL-6的水平明显升高，且它们血清浓度与脑出血量呈正相关。这提示血清CRP及IL-6的水平对脑出血患者的病情及预后的评估有一定的指导意义。
Objective To investigate the changes in the serum levels of C-reactive protein （CRP） and interleukin-6 （IL-6） in the patients with hypertensive intracerebral hemorrhage （HICH） and their meanings. Methods Seventy-five patients with HICH, who were treated in our hospital from February, 2013 to June, 2013, were divide into three groups according the volume of intracranial hematomas including small hematoma （〈30 ml） group, mediate hematoma （30-50 ml） group and large hematoma （〉50 ml） group. The serum levels of IL-6 and CRP were determined respectively by ELISA and immunonephelometry in 75 patients with HICH and in 42 health people serving as control group. Results The serum levels of CRP and IL-6 in patients with HICH were significantly higher than those in the healthy people （P〈0.05）. The serum levels of CRP and IL-6 were significantly higher in the large hematoma group than those in the mediate hematoma group （P〈0.05）, which were significantly higher than those in the small hematoma group （P〈0.05） 1, 3, 7 and 14 days after HICH. Conclusions The serum levels of CRP and IL-6 in patients with HICH were significantly higher than those in the healthy people, and they were positively related to the volume of the hematomas. It is suggested that the determinations of the serum levels of CRP and IL-6 may be helpful to assessing the hematoma volume and prognosis in the patients with HICH.
出处
《中国临床神经外科杂志》
2014年第6期348-350,共3页
Chinese Journal of Clinical Neurosurgery
