摘要
目的探讨利培酮合并小剂量阿立哌唑治疗精神分裂症时对高催乳素血症的降低作用。方法 88例符合ICD-10精神分裂症诊断标准的患者随机分为对照组(单用利培酮)44例、观察组(利培酮联合小剂量阿立哌唑)44例,进行4周对照研究。分别于治疗第0、2、4周末测定血清催乳素(PRL)水平,并采用阳性和阴性症状量表(PANSS)、锥体外系症状量表(ESRS)、副反应量表(TESS)评定疗效和不良反应。结果对照组治疗第2周末、第4周末PRL血清水平与治疗前相比差异均有统计学意义;观察组第2、4周末PRL血清水平均无显著变化。两组不良反应均较轻,总体发生率相当,联合阿立哌唑对利培酮的疗效无不良影响。结论合并小剂量阿立哌唑可显著降低利培酮引起的催乳素水平升高,安全性较高。
Objective To explore the efficacy and tolerability of aripiprazole in the adjunctive treatment for risperidone in hyperprolactinemia. Methods A total of 88 schizophrenia patients randomly divided into Risperidone associated with aripiprazole treatment group （n=44） and single Risperidone group（n=44）, for 4 weeks. Serum prolactin levels were measur weeks 0, 2, 4. Symptoms and side effects were assessed with Positive and Negative Syndrome Scale （ PANSS）, Extrapyra Symptom Rating Scale （ESRS） ,Treatment Emergent Symptom Scale （TESS） at weeks 0, 2, 4. Results Serum prolactin were reduced significantly at the second week, and the fourth week in single Risperidone group; however this difference in Risperidone associated with aripiprazole group dosed at 5 mg/day was not statistically significant before and after the study. Other side effects were less and the total prevalence of side effects was similar in two groups. Conclusion Efficacy and tolerability of aripiprazole in the adjunctive treatment for risperidone induced hyperprolactinemia is very good.
出处
《中国现代药物应用》
2013年第19期18-19,共2页
Chinese Journal of Modern Drug Application
