摘要
目的 观察瑞舒伐他汀对阵发性心房颤动（PAF）复律后维持窦性心律及P波离散度的影响.方法 选择经静脉注射胺碘酮转复后的PAF患者80例随机分为2组,对照组38例单独口服胺碘酮;治疗组42例在对照组治疗的基础上加用瑞舒伐他汀口服.两组疗程均为12个月.结果 治疗组治疗后各时间段的C-反应蛋白（CRP）水平均显著低于对照组（P均〈0.01）;两组患者治疗2周后复律成功率差异无统计学意义（P〉0.05）,治疗后1、6、12个月治疗组窦性心律维持率均显著高于对照组（P均〈0.05）;治疗组最大P波时限（P（max））、P波离散度（Pd）比治疗前和对照组显著缩短（P均〈0.05）.瑞舒伐他汀的不良反应轻微.结论 瑞舒伐他汀联合胺碘酮用于阵发性心房颤动复律后维持窦性心律效果良好,显著降低CRP水平,显著缩短最大P波时限和P波离散度,安全性好.
Objective To observe the effect of rosuvastatin on maintenance of sinus rhythm and P wave dispersion in patients with paroxysmal atrial fibrillation after the restoration of sinus rhythm. Methods 80 patients with PAF Intravenous amiodarone for the sinus rhythm were randomly divided into two groups, the control group （38 cases） received oral amioarone alone, the treatment group（42 cases） added rosuvastatin treatment on the basis of the control group. Two groups were treated for 12 months. Results After treatment, the CRP levels of all time in the treatment group were significantly lower than the control group （P all〈0.01 ）, the success rate of cardioversion of 2 groups after 2 weeks of treatment was no significant difference （P〉0.05）, tthe sinus rhythm maintenance rate of the treatment group was significantly higher than the control group at 1, 6, 12 months after treatment（P all〈0.05 ）, the Pmax, Pd of the treatment group was significantly shorter than before treatment and the control group （P all〈0.05）. Rosuvastatin side effects were minor. Conclusion It shows good effects by combining rosuvastatin and amiodarone for paroxysmal atrial fibrillation in maintaining sinus rhythm, lowering CRP level, and reducing the maximum P wave duration and P wave dispersion.
出处
《中国心血管病研究》
CAS
2010年第6期438-441,共4页
Chinese Journal of Cardiovascular Research
关键词
瑞舒伐他汀
心房颤动
阵发性
复律
窦性心律
P波离散度
Rosuvastatin
Atrial fibrillation
Paroxysmal
Cardioversion
Sinus rhythm
P wave dispersion
