摘要
目的探讨替米沙坦对高血压合并阵发性心房颤动患者的P波离散度(Pd)和P波最大时限(Pmax),左房内径及复发的影响,探讨替米沙坦的抗心律失常效应。方法将58例高血压病合并阵发性房颤患者随机分成治疗组(29例)和对照组(29例),另设正常人29例为正常组。治疗组给替米地沙坦80mg/d,1次/日,对照组给予利尿剂和钙拮抗剂。在服药前、服药3个月分别测量Pmax及Pd、左房内径及房颤发生率、复发率的情况。结果治疗组可使Pmax和Pd明显缩短(P<0.05),左房内径稍缩小(P>0.05),房颤发生率较对照组亦明显降低(P<0.01),但差异不显著(P>0.05),对照组虽也使Pmax和Pd减小,但差异不显著(P>0.05),对左房内径几乎无影响(P>0.05),房颤发生率减少,但差异不显著(P>0.05)。结论高血压合并阵发性房颤患者Pmax,Pd较正常人增大,替米沙坦可减少Pmax和Pd,减少阵发性房颤发生率,使左房内径有缩小趋势,并能改变心房的结构异常和电生理异常。
Objective To investigate the influence of ARB on P wave dispersion（Pd）, maximal time of P wave（Pmax）, LAD and recurrence rate of arterial fibrillation（AF）. Methods 58 patients who were divided into two groups at random： test group and control group （n=29 in each group）. We meas- ured the Pmax.Pd.LAD of based on the ECG at the beginning and the third month after taking medicine. Normal group （n=29） was regarded as control. We also observed the frequency of AF of the two groups during the stage of therapy. Results The ARB could decrease the Pmax and Pd （P 〈0. 05）, it decreased LAD slightly too （P〉0.05）. The ARB group could reduce the incidence of AF obviously （P〈0. 01）. The control group also reduced the incidence of AF, but no difference （P〉0.05）. Though the control group decreased the Pmax and Pd, no difference between two group （P〉0. 05）, it had almost no effect on LAD. Conclusions The ARB can decrease Pmax and Pd, at the same time, it can prevent the recurrence of AF, and it has the tendency to reduce the left atrium. It can change the structural and electro physiologic abnormality of atrium.
出处
《齐齐哈尔医学院学报》
2008年第14期1675-1676,共2页
Journal of Qiqihar Medical University
关键词
替米沙坦
心房颤动
P波离散度
高血压
Telmisartan Artrial fibrillation P-wave dispersion Essential hypertension
