摘要
甘油是酵母细胞生长代谢过程中常见的多元醇物质。尽管甘油的结构简单,代谢途径并不复杂,但是其在细胞内的生理功能十分重要。甘油代谢过程主要参与细胞的高渗透压生理调节和厌氧条件下的胞内氧化还原平衡调节。近年来许多学者在酵母细胞的甘油代谢及生理功能方面开展了深入的研究。在扼要介绍甘油生理代谢的基础上,重点阐述甘油代谢参与细胞高渗压甘油应答信号途径和氧化还原平衡调节的生理机制,同时就酵母细胞甘油合成的代谢工程进行归纳和评述。
Glycerol,a common polyol metabolite,is produced during yeast cells growth,propagation and glucose metabolism.Though glycerol structure and metabolic pathway is very simple,it plays an important physiological role in yeast cells,especially which are exposed in such stress conditions as hypertonic medium,frozen temperature and anaerobic environment.Glycerol metabolism is involved in osmoregulation and redox balance regulation.Recently,physiological function of glycerol in yeast,especially for Saccharomyces cerevisiae,were focused on and investigated widely.Glycerol metabolism was introduced succinctly,and the correlations of glycerol production and osmoregulation,redox balance are emphasized on.Moreover,metabolic engineering for glycerol biosynthesis and its future research prospects are discussed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2010年第5期140-148,共9页
China Biotechnology
关键词
酵母细胞
甘油代谢
高渗压甘油途径
氧化还原平衡
Saccharomyces cerevisiae Glycerol metabolism High osmotic glycerol pathway Redox balance
