摘要
目的了解西双版纳州傣族、布朗族、基诺族3个特有少数民族红细胞葡萄糖-6-磷酸脱氢酶(G6PD)缺乏的现况。方法采用荧光斑点试验,现况调查时对所有7岁以下儿童进行G6PD检测及问卷调查。结果 G6PD缺乏检出比例为2.2%(60/2715);男童缺乏检出比例为2.7%(37/1372)、女童为1.6%(23/1403),男童高于女童,但差异无统计学意义(P>0.05);G6PD缺乏检出比例汉族居首位为6.2%(6/96),其后依次为傣族2.6%(86/3328)、基诺族2.0%(18/904)、布朗族0.4%(4/1000),汉族高于其它民族,傣族和基诺族高于布朗族,差异均有统计学意义(P<0.01);G6PD缺乏检出比例勐腊县居首3.4%(31/902),依次景洪市1.7%(10/606),勐海县1.5%(19/1269),勐腊县高于勐海县和景洪市,差异有统计学意义(P<0.01)。结论进行人群筛检以发现携带者从而减少遗传缺陷婴儿的出生显得尤为重要,筛查人群除儿童外,重点应放在育龄人群。对筛检阳性者应进一步进行基因诊断,防止携带者婚配,降低家族遗传风险,提高出生人口素质。
Objective To obtain prevalence of Glucose-6-phosphate dehydrogenase deficiency （G6PD） among children aged 0-7 years of Dai, Bulang and Jinuo minority origin in Xishuangbanna Prefecture, Yunnan Province, China. Methods A questionnaire was administered to all children under 7 years. G6PD was determined by fluorescent spot test. Results Overall G6PD prevalence rate was 2. 2 % （60/2 715）, with 2.7 % （ 1 372） for boys, and 1.6 （23/1 403） for girls. The difference in the preva- lence rates was not statistically significant （P 〉 0. 05 ）. G6PD prevalence rate was lower （ P 〈 0. 01 ） among Dai （2.6, 86/3 328）, Jinuo （2. 0 %, 18/904）, and Bulang （0. 4 %, 4/1 000） children than the rate a- mong Han origin （6. 2 %, 6/96）. The prevalence was the highest in Mengla （3.4 % ）, followed by Jing- hong City （ 1.7 % ）, and Menghai （ 1.5 % ）. The difference in the rates was also statistically significant （ P 〈 0. 01 ）. Conclusion The prevalence rate of G6PD was not high among Dai, Bulang, and Jinou minority children as compared with the rate among children of Han nationality. Carrier screening and counseling are important among child-bearing women to prevent inheritance of the genetic disorder to children.
出处
《中国生育健康杂志》
2010年第2期86-88,共3页
Chinese Journal of Reproductive Health
