摘要
目的研究健康志愿者单剂量口服黄豆苷元胶囊的药动学。方法健康志愿者10名(男性5名,女性5名),单剂量口服黄豆苷元胶囊0.15 g,采用高效液相色谱法测定血浆中黄豆苷元的含量。用DAS软件程序进行数据处理,用SPSS软件对不同性别受试者药动学参数进行统计分析。结果受试者单剂量口服0.15 g黄豆苷元的主要药动学参数:Cmax为(162.2±37.5)ng/ml,tmax为(1.2±0.6)h,t1/2为(3.7±2.3)h,AUC0→12为(488.5±93.7)ng.h/ml,AUC0→∞为(518.4±121.8)ng.h/ml。结论健康志愿者单剂量口服黄豆苷元胶囊的体内药动学过程符合一室模型。经统计学分析,健康志愿者药动学过程不存在性别差异。
Objective To study the pharmacokinetics of Daidzein Capsules after a single oral dose in healthy volunteers.Methods Five healthy male volunteers and five healthy female volunteers were involved in the study.Each subject received a single dose of 0.15 g Daidzein Capsules.The plasma concentration was determined by high performance liquid chromatography.The pharmacokinetic parameters were calculated by DAS software and were statistically analyzed by SPSS software.Results The main pharmacokinetic parameters were as follows：Cmax was（162.2±37.5）ng/ml,tmax was（1.2±0.6）h,t1/2 was（3.7±2.3）h,AUC0→12 was（488.5±93.7）ng·h/ml,AUC0→∞ was（518.4±121.8）ng·h/ml.Conclusion The results showed that the plasma concentration-time curve of daidzein conformed to a one-compartment model and the main pharmacokinetic parameters of daidzein were not significantly different between male and female volunteers.
出处
《解放军药学学报》
CAS
2010年第1期16-18,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
黄豆苷元
高效液相色谱法
药动学
daidzein
high performance liquid chromatography
pharmacokinetics
