摘要
目的探讨党参硒多糖对急性低氧条件下肠系膜微动脉血管反应性和抗氧化酶的影响。方法SD大鼠用党参硒多糖处理后,造成低氧,观察肠系膜微动脉血管口径、血流速度和血浆中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和活性氧(ROS)含量的变化。结果治疗组与对照组比较,肠系膜微动脉血管口径变化不大,而血液流速增快,在低氧10,15,20,25 min时分别为(3.27±0.81),(2.97±0.67),(2.74±0.62)mm/s(P<0.01,P<0.05);ROS明显减少为(575.00±14.63)u/mL(P<0.01),SOD、CAT和GSH-Px活力明显增加,分别为(185.11±13.92)Nu/mL,(75.76±3.22)u/mL,(27.85±3.01)u/mL(P<0.01)。结论急性低氧可使肠系膜微动脉管径变大和血细胞流速减慢,同时体内抗氧化酶活性减弱;而党参硒多糖能增加血细胞流速,提高抗氧化酶活性。
Objective To study the effects of Se-polysaccharides in Codonopsis pilosula on mesentery microvessel response and anti-oxidation enzyme in rats with acute hypoxia.Methods SD Rats were treated with Se-polysaccharides in Codonopsis pilosula and then exposed to hypoxia.The diameter of the microvessel,speed of blood stream,the activities of superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px）,catalase（CAT）,and the content of reactive oxygen（ROS） in plasma of the rats were measured.Results Compared with the control group,the speed of the blood stream became fast gradually（3.27±0.81,2.97±0.67,2.74±0.62 mm/s at 10,15,25 minutes after hypoxia;P0.01,P0.05）.The content of ROS went down slightly（575.00±14.63 u/mL,P0.01）.The activities of SOD,CAT and GSH-Px were increased（185.11±13.92 Nu/mL,75.76±3.22 u/mL,27.85±3.01 u/mL,P0.01）.Conclusion Acute hypoxia could enlarge mesentery microvessels,slow the speed of blood stream and decrease the avtivity of anti-oxidation enzyme.Se-polysaccharides in Codonopsis pilosula could increase the speed of blood stream and the avtivity of anti-oxidation enzyme.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2010年第5期557-558,共2页
Chinese Journal of Public Health
基金
湖北省教育厅技术创新项目(J200529001)
关键词
党参硒多糖
急性低氧
肠系膜微动脉
抗氧化酶
Se-polysaccharides in Codonopsis pilosula
acute hypoxia
mesentery microvessel
anti-oxidation enzyme
