摘要
目的探讨胃黏膜上皮内瘤变组织中环氧合酶(COX)-2蛋白的表达情况及其临床意义。方法采用免疫组织化学技术,检测56例内镜活检病理证实为上皮内瘤变的标本中COX-2蛋白的表达情况。结果(1)经HE染色识别的胃黏膜组织上皮内瘤变56例中轻度不典型增生18例,中度不典型增生18例,重度不典型增生17例,原位癌3例。(2)COX-2蛋白表达在轻度不典型增生、中度不典型增生、重度不典型增生和原位癌的阳性率分别为33.33%(6/18)、50%(9/18)、70.59%(12/17)和100%(3/3),各组间比较差异显著(P<0.05)。高级别上皮内瘤变的阳性表达率(75%)明显高于低级别上皮内瘤变者(41.67%),两者比较差异显著(P<0.01)。结论检测胃黏膜上皮内瘤变组织中COX-2蛋白表达可以帮助临床识别胃黏膜上皮内瘤变组织,预测胃癌前病变的进展,为临床选择治疗方案(ESD、外科手术等)提供依据。
Objective To study the expression of cyclooxygenase（ COX） -2 protein in gastric intraepithelial neoplasia tissue and its clinical significance. Methods A total 56 cases of endoscopic biopsy confirmed intraepithelial neoplasia specimens COX-2 protein were detect by the immunohistochemical technique. Results （ 1 ） The 54 cases of the gastric mucosa intraepithelial neoplasia were confirmed by HE stainning. Amo.ng these cases, mild dysplasia 18 cases, moderate dysplasia 18 cases, severe dysplasia 17 cases carcinoma in situ 3 cases. （2）The COX-2 protein expression in mild dysplasia moderate dysplasia, severe dysplasia and carcinoma in situ of the positive rates were 33.33% ,50% ,70. 59% and 100% ,the significant difference between the two groups（ P 〈 0. 05 ）. The intraepithelial high-level positive expression rate（75% ） was significantly higher than the low-grade intraepithelial neoplasia（41.67% ） ,both were significantly different（ P 〈0. 01 ）. Conclusion The detection of gastric mucosa of COX-2 expression can be useful predict the clinical progress of gastric precancerous lesions, and provide a basis for the selection of treatment program （ ESD, surgery, etc）.
出处
《临床消化病杂志》
2010年第2期76-78,共3页
Chinese Journal of Clinical Gastroenterology
