摘要
目的:研究胃癌组织中真核细胞起始因子4E(eukaryotic initiation factor4E,eIF4E),血管内皮生长因子(vascular endothelial growth factor,VEGF)和细胞周期素D1(CyclinD1)蛋白的表达水平及其与临床病理的关系.方法:胃癌组织91例和正常胃黏膜组织30例采用免疫组织化学方法检测eIF4E,VEGF和CyclinD1的表达,分析其表达差异,并结合其临床病理资料进行综合分析.结果:与正常胃组织相比,eIF4E,VEGF和CyclinD1蛋白在胃癌组织中均呈高表达(95.6%,68.1%,84.6%vs0.0%,均P<0.01).eIF4E,VEGF和CyclinD1的阳性表达率与患者的年龄、性别以及肿瘤分化程度均无明显相关性,但随着肿瘤浸润深度加深、淋巴转移产生、临床分期提高而升高(P<0.05).eIF4E与VEGF,eIF4E与CyclinD1的表达呈正相关(r=0.407,P<0.05;r=0.780,P<0.01).结论:eIF4E,VEGF和CyclinD1的表达与胃癌的侵袭、转移密切相关,eIF4E表达与VEGF以及CyclinD1显著相关.
AIM： To investigate the expression of eukaryotic initiation factor 4E （eIF4E）, vascular endothelial growth factor （VEGF） and Cyclin D1 in gastric cancerous tissues and their correlations with the clinical pathology. METHODS： Iminunohistochemistry was used to detect the expression of eIF4E, VEGF and Cyclin D1 in 91 specimens of gastric cancer and 30 specimens of normal gastric tissues. The corresponding clinical data were analyzed retrospectively. RESULTS： In comparison with those in normal gastric mucosa, the expression of eIF4E, VEGF and Cydin D1 were significantly increased （95.6%, 68.1%, 84.6% vs 0.0%, all P 〈 0.01）, which were significantly correlated with the depth of invasion, lymph node metastasis and clinical stages （P 〈 0.05）, but not with the age, sex of patients and tumor differentiation. There was a positive correlation between eIF4E and VEGF expression （r = 0.407, P 〈 0.05） as well as between eIF4E and Cyclin D1 expression （r = 0.780, P 〈 0.01）. CONCLUSION： The expression of eIF4E, VEGF and Cyclin D1 are closely correlated with the invasion and metastasis of gastric carcinoma, and moreover, eIF4E expression is positively correlated with VEGF and Cyclin D1 expression.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第12期1304-1308,共5页
World Chinese Journal of Digestology
关键词
胃癌
真核细胞起始因子4E
血管内皮生长因子
细胞周期素D1
Gastric carcinoma
Eukaryotic initiation factor 4E
Vascular endothelial growth factor
Cyclin D1
Immunohistochemistry
